دورية أكاديمية
Evaluation of low fluoride toothpaste using primary enamel and a validated pH-cycling model.
| العنوان: | Evaluation of low fluoride toothpaste using primary enamel and a validated pH-cycling model. |
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| المؤلفون: | Velo MM; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Tabchoury CP; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil. cinthia@fop.unicamp.br., Romão DA; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Cury JA; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil. |
| المصدر: | International journal of paediatric dentistry [Int J Paediatr Dent] 2016 Nov; Vol. 26 (6), pp. 439-447. Date of Electronic Publication: 2015 Nov 05. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9107511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-263X (Electronic) Linking ISSN: 09607439 NLM ISO Abbreviation: Int J Paediatr Dent |
| أسماء مطبوعة: | Original Publication: Oxford : Blackwell Scientific Publications, c1991- |
| مواضيع طبية MeSH: | Cariostatic Agents/*chemistry , Dental Enamel/*drug effects , Fluorides/*chemistry , Toothpastes/*chemistry, Hardness ; Humans ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Surface Properties |
| مستخلص: | Aim: To develop and validate pH-cycling model for primary enamel, which was then used to evaluate the anti-caries potential of fluoride toothpastes. Design: Human primary enamel slabs were subjected to pH-cycling model for 10 days and maintained for 6 h in demineralizing solution and 18 h in remineralizing solution daily. Twice/day, the slabs were treated. To validate it, the treatments were water or solutions containing 62.5, 125, 250, and 375 μg F/mL. Commercial toothpastes containing no fluoride, 500, 1100, and 1450 μg F/g were evaluated. Demineralization was assessed by percentage of surface hardness loss (%SHL) and cross-sectional hardness (ΔS). Fluoride dose-response effect was analysed by quadratic regression and the effects of toothpastes by Tukey's test. Results: Dose-response effect was found between fluoride concentration and %SHL (R 2 = 0.7047; P < 0.01) or ΔS (R 2 = 0.4465; P < 0.01). %SHL and ΔS (mean ± SD) for the group treated with 500 μg F/g toothpaste was 36.6 ± 8.0 and 6298.5 ± 1221.3, respectively, which were significantly higher than those treated with 1100 (25.2 ± 8.7; 4565.7 ± 1122) and 1450 μg F/g (24.2 ± 5.2; 2339.1 ± 879.7) toothpastes. Conclusion: The developed pH-cycling model may be used to evaluate and compare the anti-caries potential of toothpaste formulations with low fluoride concentration because it presents dose-response effects on the reduction of primary enamel demineralization. (© 2015 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
| المشرفين على المادة: | 0 (Cariostatic Agents) 0 (Toothpastes) Q80VPU408O (Fluorides) |
| تواريخ الأحداث: | Date Created: 20151106 Date Completed: 20171023 Latest Revision: 20191210 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/ipd.12209 |
| PMID: | 26538378 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-263X |
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| DOI: | 10.1111/ipd.12209 |