دورية أكاديمية
Dynamics and role of antibodies to Plasmodium falciparum merozoite antigens in children living in two settings with differing malaria transmission intensity.
العنوان: | Dynamics and role of antibodies to Plasmodium falciparum merozoite antigens in children living in two settings with differing malaria transmission intensity. |
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المؤلفون: | Kangoye DT; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208, Ouagadougou 01, Burkina Faso; Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast (KEMRI-CGMRC), P.O. Box 230, Kilifi 80108, Kenya. Electronic address: DKangoye@kemri-wellcome.org., Mensah VA; Service de Parasitologie, Université Cheikh Anta Diop (UCAD), BP 5005 UCAD, Dakar, Senegal., Murungi LM; Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast (KEMRI-CGMRC), P.O. Box 230, Kilifi 80108, Kenya., Nkumama I; Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast (KEMRI-CGMRC), P.O. Box 230, Kilifi 80108, Kenya., Nebie I; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208, Ouagadougou 01, Burkina Faso., Marsh K; Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast (KEMRI-CGMRC), P.O. Box 230, Kilifi 80108, Kenya; Nuffield Department of Medicine, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom., Cisse B; Service de Parasitologie, Université Cheikh Anta Diop (UCAD), BP 5005 UCAD, Dakar, Senegal., Bejon P; Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast (KEMRI-CGMRC), P.O. Box 230, Kilifi 80108, Kenya; Nuffield Department of Medicine, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom., Osier FH; Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast (KEMRI-CGMRC), P.O. Box 230, Kilifi 80108, Kenya., Sirima SB; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208, Ouagadougou 01, Burkina Faso. |
مؤلفون مشاركون: | MVVC Infant Immunology Study Group |
المصدر: | Vaccine [Vaccine] 2016 Jan 02; Vol. 34 (1), pp. 160-6. Date of Electronic Publication: 2015 Nov 11. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Amsterdam, The Netherlands : Elsevier Science Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1983- |
مواضيع طبية MeSH: | Antibodies, Protozoan/*blood , Antigens, Protozoan/*immunology , Malaria/*immunology , Merozoites/*immunology , Plasmodium falciparum/*immunology, Burkina Faso/epidemiology ; Child ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Infant ; Longitudinal Studies ; Malaria/epidemiology ; Malaria/transmission ; Male ; Prospective Studies ; Senegal/epidemiology |
مستخلص: | Background: Young infants have reduced susceptibility to febrile malaria compared with older children, but the mechanism for this remains unclear. There are conflicting data on the role of passively acquired antibodies. Here, we examine antibody titres to merozoite surface antigens in the protection of children in their first two years of life in two settings with differing malaria transmission intensity and compare these titres to previously established protective thresholds. Methods: Two cohorts of children aged four to six weeks were recruited in Banfora, Burkina and Keur Soce, Senegal and followed up for two years. Malaria infections were detected by light microscopic examination of blood smears collected at active and passive case detection visits. The titres of antibodies to the Plasmodium falciparum recombinant merozoite proteins (AMA1-3D7, MSP1-19, MSP2-Dd2, and MSP3-3D7) were measured by enzyme-linked immunosorbent assay at 1-6, 9, 12, 15 and 18 months of age and compared with the protective thresholds established in Kenyan children. Results: Antibody titres were below the protective thresholds throughout the study period and we did not find any association with protection against febrile malaria. Antibodies to AMA1 and MSP1-19 appeared to be markers of exposure in the univariate analysis (and so associated with increasing risk) and adjusting for exposure reduced the strength and significance of this association. Conclusion: The antibody levels we measured are unlikely to be responsible for the apparent protection against febrile malaria seen in young infants. Further work to identify protective antibody responses might include functional assays and a wider range of antigens. (Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
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معلومات مُعتمدة: | G1002624 United Kingdom MRC_ Medical Research Council; MR/L00450X/1 United Kingdom MRC_ Medical Research Council; United Kingdom Wellcome Trust |
فهرسة مساهمة: | Investigator: JB Yaro, Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208, Ouagadougou 01, Burkina Faso.; S Debe, Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208, Ouagadougou 01, Burkina Faso.; S Traore, Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208, Ouagadougou 01, Burkina Faso.; A Ndaw, Service de Parasitologie, Université Cheikh Anta Diop (UCAD), BP 5005 UCAD, Dakar, Senegal.; B Faye, Service de Parasitologie, Université Cheikh Anta Diop (UCAD), BP 5005 UCAD, Dakar, Senegal.; I Soulama, Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208, Ouagadougou 01, Burkina Faso.; A Diarra, Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208, Ouagadougou 01, Burkina Faso.; A Tiono, Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208, Ouagadougou 01, Burkina Faso. Keywords: Antibody dynamics; Infants; Malaria; Merozoite antigens; Protective threshold |
المشرفين على المادة: | 0 (Antibodies, Protozoan) 0 (Antigens, Protozoan) |
تواريخ الأحداث: | Date Created: 20151107 Date Completed: 20161114 Latest Revision: 20220129 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC4683095 |
DOI: | 10.1016/j.vaccine.2015.10.058 |
PMID: | 26541134 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1873-2518 |
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DOI: | 10.1016/j.vaccine.2015.10.058 |