دورية أكاديمية
أعرض في EDS

Sildenafil treatment attenuates ventricular remodeling in an experimental model of aortic regurgitation.

التفاصيل البيبلوغرافية
العنوان: Sildenafil treatment attenuates ventricular remodeling in an experimental model of aortic regurgitation.
المؤلفون: Eskesen K; Johns Hopkins Medical Institutions, Division of Cardiology, Baltimore, MD USA ; Department of Cardiology, Gentofte Hospital, University of Copenhagen, Niels Andersensvej 65, 2900 Hellerup, Denmark., Olsen NT; Johns Hopkins Medical Institutions, Division of Cardiology, Baltimore, MD USA ; Department of Cardiology, Gentofte Hospital, University of Copenhagen, Niels Andersensvej 65, 2900 Hellerup, Denmark., Dimaano VL; Johns Hopkins Medical Institutions, Division of Cardiology, Baltimore, MD USA., Fritz-Hansen T; Department of Cardiology, Gentofte Hospital, University of Copenhagen, Niels Andersensvej 65, 2900 Hellerup, Denmark., Sogaard P; Department of Cardiology, Aalborg Hospital, University of Aalborg, Aalborg, Denmark., Chakir K; Johns Hopkins Medical Institutions, Division of Cardiology, Baltimore, MD USA., Steenbergen C; Johns Hopkins Medical Institutions, Division of Cardiology, Baltimore, MD USA., Kass D; Johns Hopkins Medical Institutions, Division of Cardiology, Baltimore, MD USA., Abraham TP; Johns Hopkins Medical Institutions, Division of Cardiology, Baltimore, MD USA.
المصدر: SpringerPlus [Springerplus] 2015 Oct 13; Vol. 4, pp. 592. Date of Electronic Publication: 2015 Oct 13 (Print Publication: 2015).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SpringerPlus Country of Publication: Switzerland NLM ID: 101597967 Publication Model: eCollection Cited Medium: Print ISSN: 2193-1801 (Print) Linking ISSN: 21931801 NLM ISO Abbreviation: Springerplus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Switzerland : SpringerPlus
مستخلص: Background: Currently there is no reliable medical treatment for aortic regurgitation (AR).
Methods: Thirty-nine Sprague-Dawley rats underwent creation of AR or sham operation. Treated rats were assigned to early or late institution of sildenafil therapy (100 mg/kg/day) for a total of 10 weeks. Treatment-effects were measured by serial echocardiography, invasive hemodynamic measurements, and tissue analysis.
Results: Rats assigned to early treatment developed less remodeling than untreated rats. Thus, left ventricular (LV) dilation was blunted by sildenafil with end-systolic diameter being significantly smaller (6.6 ± 0.4 vs. 7.7 ± 0.4 mm, respectively, p < 0.05). Also, LV wall thickness was significantly decreased in treated rats compared to controls (2.23 ± 0.08 vs. 2.16 ± 0.05 mm, p < 0.01). Fractional shortening was improved by treatment (p < 0.05). Myocardial fibrosis was borderline decreased by treatment (p = 0.09). Akt was increased in treated compared to controls (p < 0.05).
Conclusion: Sildenafil slightly inhibits LV remodeling and improves fractional shortening in rats with AR when treatment is initiated early.
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فهرسة مساهمة: Keywords: Animal models; Aortic regurgitation; Echocardiography; Phosphodiesterase
تواريخ الأحداث: Date Created: 20151107 Date Completed: 20151106 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4628012
DOI: 10.1186/s40064-015-1317-8
PMID: 26543727
قاعدة البيانات: MEDLINE
الوصف
تدمد:2193-1801
DOI:10.1186/s40064-015-1317-8