دورية أكاديمية
أعرض في EDS

Chewing the fat: lipid metabolism and homeostasis during M. tuberculosis infection.

التفاصيل البيبلوغرافية
العنوان: Chewing the fat: lipid metabolism and homeostasis during M. tuberculosis infection.
المؤلفون: Lovewell RR; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA., Sassetti CM; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., VanderVen BC; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA. Electronic address: bcv8@cornell.edu.
المصدر: Current opinion in microbiology [Curr Opin Microbiol] 2016 Feb; Vol. 29, pp. 30-6. Date of Electronic Publication: 2015 Nov 03.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Current Biology Country of Publication: England NLM ID: 9815056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0364 (Electronic) Linking ISSN: 13695274 NLM ISO Abbreviation: Curr Opin Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London ; New York : Current Biology, c1998-
مواضيع طبية MeSH: Host-Pathogen Interactions* , Lipid Metabolism*, Macrophages/*microbiology , Mycobacterium tuberculosis/*metabolism , Tuberculosis/*metabolism , Tuberculosis/*microbiology, Animals ; Fatty Acids/metabolism ; Foam Cells/metabolism ; Foam Cells/microbiology ; Homeostasis ; Humans ; Lipid Droplets/metabolism ; Macrophages/metabolism ; Macrophages/ultrastructure ; Metabolic Networks and Pathways/physiology ; Mice ; Mycobacterium tuberculosis/growth & development ; Tuberculosis/therapy
مستخلص: The interplay between Mycobacterium tuberculosis lipid metabolism, the immune response and lipid homeostasis in the host creates a complex and dynamic pathogen-host interaction. Advances in imaging and metabolic analysis techniques indicate that M. tuberculosis preferentially associates with foamy cells and employs multiple physiological systems to utilize exogenously derived fatty-acids and cholesterol. Moreover, novel insights into specific host pathways that control lipid accumulation during infection, such as the PPARγ and LXR transcriptional regulators, have begun to reveal mechanisms by which host immunity alters the bacterial micro-environment. As bacterial lipid metabolism and host lipid regulatory pathways are both important, yet inherently complex, components of active tuberculosis, delineating the heterogeneity in lipid trafficking within disease states remains a major challenge for therapeutic design.
(Copyright © 2015. Published by Elsevier Ltd.)
معلومات مُعتمدة: AI107774 United States AI NIAID NIH HHS; AI119122 United States AI NIAID NIH HHS; R01 AI119122 United States AI NIAID NIH HHS; AI064282 United States AI NIAID NIH HHS; AI099569 United States AI NIAID NIH HHS; United States Howard Hughes Medical Institute; AI120556 United States AI NIAID NIH HHS; AI095208 United States AI NIAID NIH HHS; R21 AI099569 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Fatty Acids)
تواريخ الأحداث: Date Created: 20151107 Date Completed: 20161108 Latest Revision: 20220310
رمز التحديث: 20231215
DOI: 10.1016/j.mib.2015.10.002
PMID: 26544033
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0364
DOI:10.1016/j.mib.2015.10.002