دورية أكاديمية
Bioaccessibility of PAHs in Fuel Soot Assessed by an in Vitro Digestive Model with Absorptive Sink: Effect of Food Ingestion.
| العنوان: | Bioaccessibility of PAHs in Fuel Soot Assessed by an in Vitro Digestive Model with Absorptive Sink: Effect of Food Ingestion. |
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| المؤلفون: | Zhang Y; Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University , Beijing 100871, P.R. China., Pignatello JJ; Department of Environmental Sciences, The Connecticut Agricultural Experiment Station , New Haven, Connecticut 06504-1106, United States., Tao S; Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University , Beijing 100871, P.R. China., Xing B; Stockbridge School of Agriculture, University of Massachusetts , Amherst, Massachusetts 01003-9246, United States. |
| المصدر: | Environmental science & technology [Environ Sci Technol] 2015 Dec 15; Vol. 49 (24), pp. 14641-8. Date of Electronic Publication: 2015 Nov 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington DC : American Chemical Society Original Publication: Easton, Pa. : American Chemical Society, c1967- |
| مواضيع طبية MeSH: | Eating*, Intestine, Small/*physiology , Polycyclic Aromatic Hydrocarbons/*pharmacokinetics , Soot/*chemistry, Bile Acids and Salts ; Biological Availability ; Digestion/physiology ; Gastrointestinal Tract/metabolism ; Humans ; Hydrogen-Ion Concentration ; Intestine, Small/metabolism ; Models, Biological ; Polycyclic Aromatic Hydrocarbons/analysis ; Silicones ; Soybean Oil/pharmacology |
| مستخلص: | We investigated the effects of changing physiological conditions in the digestive tract expected with food ingestion on the apparent bioaccessibility (Bapp) of 11 polycyclic aromatic hydrocarbons (PAHs) in a fuel soot. A previously established in vitro digestive model was applied that included silicone sheet as a third-phase absorptive sink simulating passive transfer of PAHs to intestinal epithelium in the small intestine stage. The Bapp is defined as the fraction found in the digestive fluid plus sheet after digestion. We determined that Bapp was independent of gastric pH and addition of nonlipid milk representing dietary proteins and carbohydrates, whereas it increased with bile acids concentration (2.0-10 g/L), small intestinal pH (5.00-7.35), and addition of soybean oil representing dietary lipid (100% and 200% of the mean daily ingestion by 2-5 year olds in the U.S.). Bapp of PAHs increases with small intestinal pH due to the combined effects of mass transfer promotion from nonlabile to labile sorbed states in the soot, weaker sorption of the labile state, and increasingly favorable partitioning from the digestive fluid to the silicone sink. Under fed conditions, Bapp increases with inclusion of lipids due to the combined effects of mass transfer promotion from nonlabile to labile states, and increasingly favorable partitioning into bile acid micelles. Our results indicate significant variability in soot PAH bioaccessibility within the range of physiological conditions experienced by humans, and suggest that bioaccessibility will increase with coconsumption of food, especially food with high fat content. |
| المشرفين على المادة: | 0 (Bile Acids and Salts) 0 (Polycyclic Aromatic Hydrocarbons) 0 (Silicones) 0 (Soot) 8001-22-7 (Soybean Oil) |
| تواريخ الأحداث: | Date Created: 20151110 Date Completed: 20160702 Latest Revision: 20181202 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1021/acs.est.5b04342 |
| PMID: | 26551410 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5851 |
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| DOI: | 10.1021/acs.est.5b04342 |