التفاصيل البيبلوغرافية
| العنوان: |
[Analysis of Non-serotype b Encapsulated Haemophilus influenzae Isolated from Pediatric Patients]. |
| المؤلفون: |
Kutsuna S, Hoshino T, Fukasawa C, Tokutake S, Okui H, Sawada K, Sato H, Takahashi Y, Ishiwada N |
| المصدر: |
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases [Kansenshogaku Zasshi] 2015 Mar; Vol. 89 (2), pp. 237-43. |
| نوع المنشور: |
Journal Article |
| اللغة: |
Japanese |
| بيانات الدورية: |
Publisher: Nihon Densenbyō Gakkai Country of Publication: Japan NLM ID: 0236671 Publication Model: Print Cited Medium: Print ISSN: 0387-5911 (Print) Linking ISSN: 03875911 NLM ISO Abbreviation: Kansenshogaku Zasshi Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Tōkyō, Nihon Densenbyō Gakkai. |
| مواضيع طبية MeSH: |
Haemophilus influenzae/*isolation & purification, Bacterial Capsules ; Child ; Child, Preschool ; Drug Resistance, Bacterial ; Haemophilus influenzae/drug effects ; Humans ; Infant ; Serogroup |
| مستخلص: |
We analyzed non-serotype b encapsulated Haemophilus influenzae (non-b Hi) isolated from pediatric patients at Chiba Children's Hospital during 2000-2012. Among 3,532 clinical isolates of H. influenzae, there were 57 (1.6%) strains of non-b Hi, 152 (4.3%) of serotype b H. influenzae (Hib), and 3,323 (94.1%) of non-typeable H. influenzae (NTHi). Fifty-seven strains of non-b Hi were serotyped useing the slide agglutination test and PCR. Twenty-nine strains were identified as type e (Hie) and 28 as type f (Hif), and the results according to the slide agglutination test and PCR were completely identical. Whereas 52 of 57 strains (91.2%) were isolated from respiratory specimen, only one Hif strain (1.8%) was isolated from a sterile site. There were 47 (82.4%) β-lactamase-non-producing ampicillin (ABPC)-sensitive strains (BLNAS), 5 (8.8%) β-lactamase-producing strains (BLP), and only 1 (1.8%) β-lactamase-non-producing ABPC-resistant strain (BLNAR). Thus the frequency of non-b Hi was lower than that of Hib. The source of non-b Hi was similar to that of NTHi, which was mainly isolated from respiratory specimen. Antimicrobial resistant pattern of non-b Hi was different from that of Hib in which the frequency of BLP was relatively high, and NTHi in which that of BLNAR was high. An increase of invasive H. influenzae infections caused by NTHi, Hie, and Hif was reported in the countries where Hib vaccine had been widely used. Because it is assumed that invasive non-Hib infection will be predominant in the near future in Japan, serotyping of invasive strains is crucial. Continuous monitoring of distribution of non-b Hi in the clinical isolates of H. influenzae is also important. |
| تواريخ الأحداث: |
Date Created: 20151111 Date Completed: 20160104 Latest Revision: 20201209 |
| رمز التحديث: |
20221213 |
| DOI: |
10.11150/kansenshogakuzasshi.89.237 |
| PMID: |
26552120 |
| قاعدة البيانات: |
MEDLINE |
