دورية أكاديمية
أعرض في EDS

Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk.

التفاصيل البيبلوغرافية
العنوان: Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk.
المؤلفون: Xia Z; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., White CC; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Owen EK; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA., Von Korff A; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA., Clarkson SR; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA., McCabe CA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Cimpean M; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA., Winn PA; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA., Hoesing A; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA., Steele SU; Division of Neuroimmunology and Neurovirology, National Institute for Neurologic Diseases and Stroke, Bethesda, MD., Cortese IC; Division of Neuroimmunology and Neurovirology, National Institute for Neurologic Diseases and Stroke, Bethesda, MD., Chitnis T; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Weiner HL; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Reich DS; Division of Neuroimmunology and Neurovirology, National Institute for Neurologic Diseases and Stroke, Bethesda, MD., Chibnik LB; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., De Jager PL; Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
المصدر: Annals of neurology [Ann Neurol] 2016 Feb; Vol. 79 (2), pp. 178-89. Date of Electronic Publication: 2015 Dec 09.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Wiley-Liss
Original Publication: Boston, Little, Brown.
مواضيع طبية MeSH: Environment* , Genetic Predisposition to Disease* , Multiple Sclerosis*/epidemiology , Multiple Sclerosis*/etiology , Multiple Sclerosis*/genetics, Adult ; Family ; Female ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Assessment ; Risk Factors ; United States/epidemiology
مستخلص: The Genes and Environment in Multiple Sclerosis project establishes a platform to investigate the events leading to multiple sclerosis (MS) in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using an integrated genetic and environmental risk score, we identified subjects with twice the MS risk when compared to the average family member, and we report an initial incidence rate in these subjects that is 30 times greater than that of sporadic MS. We discuss the feasibility of large-scale studies of asymptomatic at-risk subjects that leverage modern tools of subject recruitment to execute collaborative projects.
(© 2015 American Neurological Association.)
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معلومات مُعتمدة: K08 NS079493 United States NS NINDS NIH HHS; K25 AG041906 United States AG NIA NIH HHS; K08-NS079493 United States NS NINDS NIH HHS; United States Intramural NIH HHS
تواريخ الأحداث: Date Created: 20151120 Date Completed: 20160617 Latest Revision: 20220330
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4778957
DOI: 10.1002/ana.24560
PMID: 26583565
قاعدة البيانات: MEDLINE
الوصف
تدمد:1531-8249
DOI:10.1002/ana.24560