دورية أكاديمية
Intraoperative 3D Navigation for Single or Multiple 125I-Seed Localization in Breast-Preserving Cancer Surgery.
| العنوان: | Intraoperative 3D Navigation for Single or Multiple 125I-Seed Localization in Breast-Preserving Cancer Surgery. |
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| المؤلفون: | Pouw B; From the Departments of *Nuclear Medicine, and †Surgical Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands., de Wit-van der Veen LJ, van Duijnhoven F, Rutgers EJ, Stokkel MP, Valdés Olmos RA, Vrancken Peeters MJ |
| المصدر: | Clinical nuclear medicine [Clin Nucl Med] 2016 May; Vol. 41 (5), pp. e216-20. |
| نوع المنشور: | Case Reports; Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, Lippincott. |
| مواضيع طبية MeSH: | Tomography, Emission-Computed, Single-Photon*, Breast Neoplasms/*diagnostic imaging, Adult ; Aged ; Breast Neoplasms/surgery ; Female ; Humans ; Iodine Radioisotopes ; Middle Aged ; Radiopharmaceuticals ; Surgery, Computer-Assisted/methods |
| مستخلص: | Background: Mammographic screening has led to the identification of more women with nonpalpable breast cancer, many of them to be treated with breast-preserving surgery. To accomplish radical tumor excision, adequate localization techniques such as radioactive seed localization (RSL) are required. For RSL, a radioactive I-seed is implanted central in the tumor to enable intraoperative localization using a γ-probe. In case of extensive tumor or multifocal carcinoma, multiple I-seeds can be used to delineate the involved area. Preoperative imaging is performed different from surgical positioning; therefore, exact I-seed depth remains unknown during surgery. Patients and Methods: Twenty patients (mean age, 56.8 years) with 25 implanted I-seeds scheduled for RSL were included. Sixteen patients had 1 I-seed implanted in the primary lesion, 3 patients had 2 I-seeds, and 1 patient had 3 I-seeds. Freehand SPECT localized I-seeds by measuring γ-counts from different directions, all registered by an optical tracking system. A reconstruction and visualization algorithm enabled 3-dimensional (3D) navigation toward the I-seeds. Results: Freehand SPECT visualized all I-seeds in primary tumors and provided preincision depth information. The deviation, mean (SD), between the freehand SPECT depth and the surgical depth estimation was 1.9 (2.1) mm (range, 0-7 mm). Three-dimensional freehand SPECT was especially useful identifying multiple implanted I-seeds because the conventional γ-probe has more difficulty discriminating I-seeds transcutaneous. Conclusions: Freehand SPECT with 3D navigation is a valuable tool in RSL for both single and multiple implanted I-seeds in breast-preserving cancer surgery. Freehand SPECT provides continuous updating 3D imaging with information about depth and location of the I-seeds contributing to adequate excision of nonpalpable breast cancer. |
| المشرفين على المادة: | 0 (Iodine Radioisotopes) 0 (Radiopharmaceuticals) |
| تواريخ الأحداث: | Date Created: 20151124 Date Completed: 20161213 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/RLU.0000000000001081 |
| PMID: | 26595340 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-0229 |
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| DOI: | 10.1097/RLU.0000000000001081 |