دورية أكاديمية
أعرض في EDS

Chemical composition modulates the adverse effects of particles on the mucociliary epithelium.

التفاصيل البيبلوغرافية
العنوان: Chemical composition modulates the adverse effects of particles on the mucociliary epithelium.
المؤلفون: Carvalho-Oliveira R; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, Universidade de São Paulo, São Paulo, SP, Brazil., Pires-Neto RC; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, Universidade de São Paulo, São Paulo, SP, Brazil., Bustillos JO; Instituto de Energia e Pesquisa Nuclear, São Paulo, SP, Brazil., Macchione M; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, Universidade de São Paulo, São Paulo, SP, Brazil., Dolhnikoff M; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, Universidade de São Paulo, São Paulo, SP, Brazil., Saldiva PH; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, Universidade de São Paulo, São Paulo, SP, Brazil., Garcia ML; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, Universidade de São Paulo, São Paulo, SP, Brazil.
المصدر: Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2015 Oct; Vol. 70 (10), pp. 706-13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: Print Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2022- : [New York] : Elsevier
Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]-
مواضيع طبية MeSH: Mucociliary Clearance* , Mucus*/chemistry, Particulate Matter/*chemistry , Particulate Matter/*toxicity , Steel/*chemistry, Animals ; Anura ; Cilia ; Epithelium ; Gas Chromatography-Mass Spectrometry ; Palate/cytology ; Spectrometry, X-Ray Emission
مستخلص: Objective: We compared the adverse effects of two types of real ambient particles; i.e., total suspended particles from an electrostatic precipitator of a steel mill and fine air particles from an urban ambient particulate matter of 2.5 µm, on mucociliary clearance.
Method: Mucociliary function was quantified by mucociliary transport, ciliary beating frequency and the amount of acid and neutral mucous in epithelial cells through morphometry of frog palate preparations. The palates were immersed in one of the following solutions: total suspended particles (0.1 mg/mL), particulate matter 2.5 µm 0.1 mg/mL (PM0.1) or 3.0 mg/mL (PM3.0) and amphibian Ringer's solution (control). Particle chemical compositions were determined by X-ray fluorescence and gas chromatography/mass spectrometry.
Results: Exposure to total suspended particles and PM3.0 decreased mucociliary transport. Ciliary beating frequency was diminished by total suspended particles at all times during exposure, while particulate matter of 2.5 µm did not elicit changes. Particulate matter of 2.5 µm reduced epithelial mucous and epithelium thickness, while total suspended particles behaved similarly to the control group. Total suspended particles exhibited a predominance of Fe and no organic compounds, while the particulate matter 2.5 µm contained predominant amounts of S, Fe, Si and, to a lesser extent, Cu, Ni, V, Zn and organic compounds.
Conclusion: Our results showed that different compositions of particles induced different airway epithelial responses, emphasizing that knowledge of their individual characteristics may help to establish policies aimed at controlling air pollution.
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المشرفين على المادة: 0 (Particulate Matter)
12597-69-2 (Steel)
تواريخ الأحداث: Date Created: 20151125 Date Completed: 20160315 Latest Revision: 20220629
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4602376
DOI: 10.6061/clinics/2015(10)09
PMID: 26598085
قاعدة البيانات: MEDLINE
الوصف
تدمد:1980-5322
DOI:10.6061/clinics/2015(10)09