دورية أكاديمية
Economic Analysis of Immunization Strategies for PRRS Control [corrected].
| العنوان: | Economic Analysis of Immunization Strategies for PRRS Control [corrected]. |
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| المؤلفون: | Linhares DC; Veterinary Diagnostic and Production Animal Medicine Department, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America., Johnson C; Swine Health Department, The Maschhoffs LLC, Carlyle, Illinois, United States of America., Morrison RB; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, United States of America. |
| المصدر: | PloS one [PLoS One] 2015 Dec 16; Vol. 10 (12), pp. e0144265. Date of Electronic Publication: 2015 Dec 16 (Print Publication: 2015). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Porcine Reproductive and Respiratory Syndrome/*prevention & control , Porcine respiratory and reproductive syndrome virus/*immunology , Vaccination/*economics , Vaccination/*methods , Viral Vaccines/*immunology, Animals ; Models, Theoretical ; Swine |
| مستخلص: | Porcine reproductive and respiratory syndrome virus (PRRSv) is a swine-specific pathogen that causes significant increases in production costs. When a breeding herd becomes infected, in an attempt to hasten control and elimination of PRRSv, some veterinarians have adopted a strategy called load-close-expose which consists of interrupting replacement pig introductions into the herd for several weeks (herd closure) and exposing the whole herd to a replicating PRRSv to boost herd immunity. Either modified-live virus (MLV) vaccine or live field-virus inoculation (FVI) is used. This study consisted of partial budget analyses to compare MLV to FVI as the exposure method of load-close-expose program to control and eliminate PRRSv from infected breeding herds, and secondly to estimate benefit / cost of vaccinating sow herds preventatively. Under the assumptions used in this study, MLV held economic advantage over FVI. However, sensitivity analysis revealed that decreasing margin over variable costs below $ 47.32, or increasing PRRSv-attributed cost above $18.89 or achieving time-to-stability before 25 weeks resulted in advantage of FVI over MLV. Preventive vaccination of sow herds was beneficial when the frequency of PRRSv infection was at least every 1 year and 9 months [corrected]. The economics of preventative vaccination was minimally affected by cost attributed to field-type PRRSv infection on growing pigs or by the breeding herd productivity level. The models developed and described in this paper provide valuable tools to assist veterinarians in their efforts to control PRRSv. |
| التعليقات: | Erratum in: PLoS One. 2016;11(4):e0150444. (PMID: 27088727) |
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| المشرفين على المادة: | 0 (Viral Vaccines) |
| تواريخ الأحداث: | Date Created: 20151218 Date Completed: 20160630 Latest Revision: 20220408 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4682627 |
| DOI: | 10.1371/journal.pone.0144265 |
| PMID: | 26673898 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0144265 |