دورية أكاديمية
Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty.
| العنوان: | Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty. |
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| المؤلفون: | Freire AV; Centro de Investigaciones Endocrinolx00F3;gicas x2018;Dr. Cx00E9;sar Bergadx00E1;' (CEDIE), CONICET - FEI - Divisix00F3;n de Endocrinologx00ED;a, Hospital de Nix00F1;os x2018;Ricardo Gutix00E9;rrez', Buenos Aires, Argentina., Gryngarten MG, Ballerini MG, Arcari AJ, Escobar ME, Bergadá I, Ropelato MG |
| المصدر: | Hormone research in paediatrics [Horm Res Paediatr] 2016; Vol. 85 (1), pp. 58-64. Date of Electronic Publication: 2015 Dec 17. |
| نوع المنشور: | Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 101525157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1663-2826 (Electronic) Linking ISSN: 16632818 NLM ISO Abbreviation: Horm Res Paediatr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel : Karger |
| مواضيع طبية MeSH: | Estradiol/*blood , Puberty, Precocious/*blood , Puberty, Precocious/*drug therapy , Triptorelin Pamoate/*administration & dosage, Child ; Female ; Follow-Up Studies ; Humans ; Prospective Studies |
| مستخلص: | Background: Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls. Aims: To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy. Methods: A prospective study was performed in 43 CPP girls. Serum luteinizing hormone and follicle-stimulating hormone at 3 h (LH-3h, FSH-3h) and estradiol at 24 h (E2-24h) after injection of depot triptorelin 3.75 mg were measured, at first dose and at 3, 6, 12, 18 and 24 months of treatment. Results: E2-24h after depot triptorelin was >100 pg/ml after the first dose. Estradiol response (E2-24h) fell to levels <14 pg/ml in 78 out of 82 follow-up visits along 2 years of therapy. Concomitantly, LH-3h and FSH-3h were <4.0 and <6.3 IU/l, respectively. In 4 patients with inadequate treatment, E2-24h, LH-3h and FSH-3h rose to pubertal values similar to those observed at first dose. Conclusion: Estradiol (<14 pg/ml) assessment 24 h after depot triptorelin administration is a reliable and simple manner to confirm ovarian suppression in CPP girls during treatment. (© 2015 S. Karger AG, Basel.) |
| المشرفين على المادة: | 08AN7WA2G0 (Triptorelin Pamoate) 4TI98Z838E (Estradiol) |
| تواريخ الأحداث: | Date Created: 20151218 Date Completed: 20161024 Latest Revision: 20190221 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1159/000442523 |
| PMID: | 26675317 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1663-2826 |
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| DOI: | 10.1159/000442523 |