دورية أكاديمية
أعرض في EDS

Host microbiota modulates development of social preference in mice.

التفاصيل البيبلوغرافية
العنوان: Host microbiota modulates development of social preference in mice.
المؤلفون: Arentsen T; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Raith H; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Qian Y; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Forssberg H; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Diaz Heijtz R; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden; rochellys.heijtz@ki.se.
المصدر: Microbial ecology in health and disease [Microb Ecol Health Dis] 2015 Dec 15; Vol. 26, pp. 29719. Date of Electronic Publication: 2015 Dec 15 (Print Publication: 2015).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: Sweden NLM ID: 8913476 Publication Model: eCollection Cited Medium: Print ISSN: 0891-060X (Print) Linking ISSN: 0891060X NLM ISO Abbreviation: Microb Ecol Health Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2016-2018 : Philadelphia, PA : Taylor & Francis
Original Publication: Chichester [Sussex] ; New York : Wiley, c1988-
مستخلص: Background: Mounting evidence indicates that the indigenous gut microbiota exerts long-lasting programming effects on brain function and behaviour.
Objective: In this study, we used the germ-free (GF) mouse model, devoid of any microbiota throughout development, to assess the influence of the indigenous microbiota on social preference and repetitive behaviours (e.g. self-grooming).
Methods and Results: Using the three-chambered social approach task, we demonstrate that when adult GF mice were given a choice to spend time with a novel mouse or object, they spent significantly more time sniffing and interacting with the stimulus mouse compared to conventionally raised mice (specific pathogen-free, SPF). Time spent in repetitive self-grooming behaviour, however, did not differ between GF and SPF mice. Real-time PCR-based gene expression analysis of the amygdala, a key region that is part of the social brain network, revealed a significant reduction in the mRNA levels of total brain-derived neurotrophic factor (BDNF), BDNF exon I-, IV-, VI-, IX-containing transcripts, and NGFI-A (a signalling molecule downstream of BDNF) in GF mice compared to SPF mice.
Conclusion: These results suggest that differential regulation of BDNF exon transcripts in the amygdala by the indigenous microbes may contribute to the altered social development of GF mice.
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فهرسة مساهمة: Keywords: BDNF; amygdala; brain development; gene expression; germ-free mice; synaptic plasticity genes
تواريخ الأحداث: Date Created: 20151219 Date Completed: 20151218 Latest Revision: 20220408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4683992
DOI: 10.3402/mehd.v26.29719
PMID: 26679775
قاعدة البيانات: MEDLINE
الوصف
تدمد:0891-060X
DOI:10.3402/mehd.v26.29719