دورية أكاديمية
N6-Methylated Adenosine in RNA: From Bacteria to Humans.
| العنوان: | N6-Methylated Adenosine in RNA: From Bacteria to Humans. |
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| المؤلفون: | Sergiev PV; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia. Electronic address: petya@genebee.msu.su., Golovina AY; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia., Osterman IA; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia., Nesterchuk MV; Skolkovo Institute for Science and Technology, Moscow 143025, Russia., Sergeeva OV; Skolkovo Institute for Science and Technology, Moscow 143025, Russia., Chugunova AA; Skolkovo Institute for Science and Technology, Moscow 143025, Russia., Evfratov SA; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia., Andreianova ES; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia., Pletnev PI; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia., Laptev IG; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia., Petriukov KS; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia., Navalayeu TI; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia., Koteliansky VE; Skolkovo Institute for Science and Technology, Moscow 143025, Russia., Bogdanov AA; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia., Dontsova OA; Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia. |
| المصدر: | Journal of molecular biology [J Mol Biol] 2016 May 22; Vol. 428 (10 Pt B), pp. 2134-45. Date of Electronic Publication: 2015 Dec 19. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: 1959- : London : Academic Press |
| مواضيع طبية MeSH: | Adenosine/*analogs & derivatives , Adenosine/*metabolism , Escherichia coli/*metabolism , RNA/*metabolism, Humans ; Methylation ; Methyltransferases/metabolism |
| مستخلص: | N6-methyladenosine (m(6)A) is ubiquitously present in the RNA of living organisms from Escherichia coli to humans. Methyltransferases that catalyze adenosine methylation are drastically different in specificity from modification of single residues in bacterial ribosomal or transfer RNA to modification of thousands of residues spread among eukaryotic mRNA. Interactions that are formed by m(6)A residues range from RNA-RNA tertiary contacts to RNA-protein recognition. Consequences of the modification loss might vary from nearly negligible to complete reprogramming of regulatory pathways and lethality. In this review, we summarized current knowledge on enzymes that introduce m(6)A modification, ways to detect m(6)A presence in RNA and the functional role of this modification everywhere it is present, from bacteria to humans. (Copyright © 2015 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: RNA modification; m(6)A; methyltransferase; rlmF; rlmJ |
| المشرفين على المادة: | 63231-63-0 (RNA) CLE6G00625 (N-methyladenosine) EC 2.1.1.- (Methyltransferases) K72T3FS567 (Adenosine) |
| تواريخ الأحداث: | Date Created: 20151229 Date Completed: 20170612 Latest Revision: 20210806 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jmb.2015.12.013 |
| PMID: | 26707202 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1089-8638 |
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| DOI: | 10.1016/j.jmb.2015.12.013 |