دورية أكاديمية
A pilot study to determine the normal haematological indices for young Malawian adults in Blantyre, Malawi.
| العنوان: | A pilot study to determine the normal haematological indices for young Malawian adults in Blantyre, Malawi. |
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| المؤلفون: | Chisale MR; Laboratory Section, Mzuzu Central Hospital, Mzuzu, Malawi., Kumwenda P; Department of Biomedical Sciences, Mzuzu University, Mzuzu, Malawi., Ngwira M; Department of Biomedical Sciences, Mzuzu University, Mzuzu, Malawi., M'baya B; Malawi Blood Transfusion Service, Blantyre, Malawi., Chosamata BI; Department of Pathology and Laboratory Sciences, College of Medicine, University of Malawi, Blantyre Malawi., Mwapasa V; Department of Public Health, College of Medicine, University of Malawi, Blantyre, Malawi. |
| المصدر: | Malawi medical journal : the journal of Medical Association of Malawi [Malawi Med J] 2015 Sep; Vol. 27 (3), pp. 96-100. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Montfort Press for the Medical Association of Malawi Country of Publication: Malawi NLM ID: 9500170 Publication Model: Print Cited Medium: Internet ISSN: 1995-7270 (Electronic) Linking ISSN: 19957262 NLM ISO Abbreviation: Malawi Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Lilongwe, Malawi : Published by Montfort Press for the Medical Association of Malawi, [1990- |
| مواضيع طبية MeSH: | Blood Donors*, Blood Chemical Analysis/*standards , Hematologic Tests/*standards, Adult ; Cross-Sectional Studies ; Female ; Hemoglobins/analysis ; Humans ; Malawi ; Male ; Pilot Projects ; Reference Values ; Young Adult |
| مستخلص: | Background: Reference ranges for haematological and other laboratory tests in most African countries are based on populations in Europe and America and, because of environmental and genetic factors, these may not accurately reflect the normal reference ranges in African populations. Aim: To determine the distribution of haematological parameters in healthy individuals residing in Blantyre, Malawi. We also examined the effect of sociodemographic and nutritional factors on the haematological variables. Methods: We conducted a proof-of-concept cross-sectional study, involving 105 healthy blood donors at Malawi Blood Transfusion Service in Blantyre. Eligible participants were HIV-negative males and females, aged 19 to 35 years, who did not have any evidence of acute or chronic illness, or blood-borne infection. We performed the haematological tests at the Malawi-Liverpool Wellcome Trust laboratory in Blantyre, and the screening tests at Malawi Blood Transfusion Service laboratories. Results: Out of 170 consenting healthy volunteers, haematological results were available for 105 participants. The proportions of results which were below the lower limit of the manufacturer's reference ranges were 35.2% (37/105) for haemoglobin, 15.2% (16/105) for neutrophils, 23.8% (25/105) for eosinophils, and 88.6 % (93/105) for basophils. The proportions of results that were above the upper limit of the manufacturer's reference ranges were 9.5% (10/105) for platelets and 12.4% (13/105) for monocytes. We also observed that the mean leucocyte and basophil counts were significantly higher in males than females (p = 0.042 and p = 0.015, respectively). There were no statistically significant differences in haematological results observed among different ethnic, age, and body mass index groups. Conclusions: Over half of otherwise healthy study participants had at least one abnormal haematological result, using previously established foreign standards. More detailed studies are needed to establish locally relevant normal ranges for different age groups and other demographic characteristics of the Malawian population. This will lead to accurate interpretation of laboratory results. |
| References: | J Clin Pathol. 1996 Aug;49(8):664-6. (PMID: 8881919) Clin Diagn Lab Immunol. 1999 May;6(3):410-4. (PMID: 10225845) Blood. 1954 Oct;9(10):999-1007. (PMID: 13208753) J Immunol. 2006 Dec 1;177(11):8086-94. (PMID: 17114483) Am J Hum Genet. 2008 Jan;82(1):81-7. (PMID: 18179887) Trop Med Int Health. 2008 May;13(5):612-25. (PMID: 18331386) Vaccine. 2008 May 23;26(22):2788-95. (PMID: 18440674) PLoS One. 2009;4(10):e7302. (PMID: 19806184) Eur J Haematol. 2009 Dec 1;83(6):586-94. (PMID: 19659559) Malar J. 2010;9:107. (PMID: 20409342) Blood. 2010 Jul 1;115(26):5289-99. (PMID: 20040767) Hum Genet. 2011 Mar;129(3):307-17. (PMID: 21153663) PLoS One. 2011;6(6):e21040. (PMID: 21713038) PLoS Genet. 2009 Jan;5(1):e1000360. (PMID: 19180233) Eur J Immunol. 2009 Jun;39(6):1597-607. (PMID: 19499525) PLoS One. 2009;4(7):e6470. (PMID: 19649242) PLoS One. 2008;3(10):e3327. (PMID: 18833329) Blood. 2000 Sep 1;96(5):1681-4. (PMID: 10961863) Clin Diagn Lab Immunol. 2004 Jan;11(1):29-34. (PMID: 14715541) Trans R Soc Trop Med Hyg. 1979;73(1):111-2. (PMID: 442169) Ethiop Med J. 1979 Jan;17(1):5-8. (PMID: 488078) Trop Geogr Med. 1982;34(4):333-9. (PMID: 7168002) East Afr Med J. 1984 Jun;61(6):482-5. (PMID: 6545190) Haematologia (Budap). 1988;21(1):57-63. (PMID: 3396976) Ir Med J. 1989 Jun;82(2):68-9. (PMID: 2759825) Arch Pathol Lab Med. 1990 Jul;114(7):715-9. (PMID: 2363629) Acta Genet Med Gemellol (Roma). 1993;42(3-4):245-52. (PMID: 7871941) East Afr Med J. 1995 Jan;72(1):19-24. (PMID: 7781549) |
| المشرفين على المادة: | 0 (Hemoglobins) |
| تواريخ الأحداث: | Date Created: 20151231 Date Completed: 20160505 Latest Revision: 20220408 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4688870 |
| DOI: | 10.4314/mmj.v27i3.5 |
| PMID: | 26715954 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1995-7270 |
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| DOI: | 10.4314/mmj.v27i3.5 |