دورية أكاديمية
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Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study.

التفاصيل البيبلوغرافية
العنوان: Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study.
المؤلفون: Reddon H; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada., Gerstein HC; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Engert JC; Departments of Medicine and Human Genetics, McGill University, Montreal, QC, Canada., Mohan V; Madras Diabetes Research Foundation, Chennai, India., Bosch J; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada., Desai D; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada., Bailey SD; Departments of Medicine and Human Genetics, McGill University, Montreal, QC, Canada., Diaz R; ECLA-Academic Research Organization, Rosario, Argentina., Yusuf S; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Anand SS; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Meyre D; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
المصدر: Scientific reports [Sci Rep] 2016 Jan 04; Vol. 6, pp. 18672. Date of Electronic Publication: 2016 Jan 04.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Genetic Predisposition to Disease* , Motor Activity*, Obesity/*epidemiology , Obesity/*genetics, Adult ; Alleles ; Body Mass Index ; Ethnicity/genetics ; Female ; Follow-Up Studies ; Genetic Association Studies ; Genotype ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Patient Outcome Assessment ; Polymorphism, Single Nucleotide ; Risk
مستخلص: Physical activity (PA) has been shown to reduce the impact of FTO variation and obesity genetic risk scores (GRS) on BMI. We examined this interaction using a quantitative measure of PA and two adiposity indexes in a longitudinal multi-ethnic study. We analyzed the impact of PA on the association between 14 obesity predisposing variants (analyzed independently and as a GRS) and baseline/follow-up obesity measures in the multi-ethnic prospective cohort EpiDREAM (17423 participants from six ethnic groups). PA was analyzed using basic (low-moderate-high) and quantitative measures (metabolic equivalents (METS)), while BMI and the body adiposity index (BAI) were used to measure obesity. Increased PA was associated with decreased BMI/BAI at baseline/follow-up. FTO rs1421085, CDKAL1 rs2206734, TNNl3K rs1514176, GIPR rs11671664 and the GRS were associated with obesity measures at baseline and/or follow-up. Risk alleles of three SNPs displayed nominal associations with increased (NTRK2 rs1211166, BDNF rs1401635) or decreased (NPC1 rs1805081) basic PA score independently of BMI/BAI. Both basic and quantitative PA measures attenuated the association between FTO rs1421085 risk allele and BMI/BAI at baseline and follow-up. Our results show that physical activity can blunt the genetic effect of FTO rs1421085 on adiposity by 36-75% in a longitudinal multi-ethnic cohort.
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تواريخ الأحداث: Date Created: 20160105 Date Completed: 20161213 Latest Revision: 20220318
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC4698633
DOI: 10.1038/srep18672
PMID: 26727462
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/srep18672