دورية أكاديمية
أعرض في EDS

Clinical 3-tesla FLAIR* MRI improves diagnostic accuracy in multiple sclerosis.

التفاصيل البيبلوغرافية
العنوان: Clinical 3-tesla FLAIR* MRI improves diagnostic accuracy in multiple sclerosis.
المؤلفون: George IC; Division of Neuroimmunology and Neurovirology, NINDS, National Institutes of Health (NIH), Bethesda, MD, USA/Yale University, New Haven, CT, USA., Sati P; Division of Neuroimmunology and Neurovirology, NINDS, National Institutes of Health (NIH), Bethesda, MD, USA., Absinta M; Division of Neuroimmunology and Neurovirology, NINDS, National Institutes of Health (NIH), Bethesda, MD, USA/ Raffaele Scientific Institute, Milan, Italy., Cortese IC; Division of Neuroimmunology and Neurovirology, NINDS, National Institutes of Health (NIH), Bethesda, MD, USA., Sweeney EM; Division of Neuroimmunology and Neurovirology, NINDS, National Institutes of Health (NIH), Bethesda, MD, USA/ Johns Hopkins School of Public Health, Baltimore, MD, USA., Shea CD; Division of Neuroimmunology and Neurovirology, NINDS, National Institutes of Health (NIH), Bethesda, MD, USA., Reich DS; Translational Neuroradiology Unit, Division of Neuroimmunology and Neurovirology, NINDS, National Institutes of Health (NIH), Bethesda, MD, USA/Johns Hopkins School of Public Health, Baltimore, MD, USA reichds@ninds.nih.gov.
المصدر: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2016 Oct; Vol. 22 (12), pp. 1578-1586. Date of Electronic Publication: 2016 Jan 14.
نوع المنشور: Journal Article; Research Support, N.I.H., Intramural
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 9509185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0970 (Electronic) Linking ISSN: 13524585 NLM ISO Abbreviation: Mult Scler Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : London : SAGE Publications
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1995-
مواضيع طبية MeSH: Cerebral Veins/*diagnostic imaging , Magnetic Resonance Imaging/*methods , Multiple Sclerosis/*diagnostic imaging, Adult ; Female ; Humans ; Magnetic Resonance Imaging/standards ; Male ; Middle Aged
مستخلص: Objective: To evaluate clinical fluid-attenuated inversion recovery (FLAIR)* 3T magnetic resonance imaging (MRI), which is sensitive to perivenular inflammatory demyelinating lesions, in diagnosing multiple sclerosis (MS).
Background: Central veins may be a distinguishing feature of MS lesions. FLAIR*, a combined contrast derived from clinical MRI scans, has not been studied as a clinical tool for diagnosing MS.
Methods: Two experienced MS neurologists evaluated 87 scan pairs (T 2 -FLAIR/FLAIR*), separately and side-by-side, from 68 MS cases, 8 healthy volunteers, and 11 individuals with other neurological diseases. Raters judged cases based on experience, published criteria, and a visual assessment of the "40% rule," whereby MS is favored if >40% of lesions demonstrate a central vein. Diagnostic accuracy was determined with area under the receiver operating characteristic curve (AUC), and inter-rater reliability was assessed with Cohen's kappa (κ).
Results: Diagnostic accuracy was high: rater 1, AUC 0.94 (95% confidence interval: 0.89, 0.97) for T 2 -FLAIR, 0.95 (0.92, 0.98) for FLAIR*; rater 2, 0.94 (0.90, 0.98) and 0.90 (0.85, 0.95). AUC improved when images were considered together: rater 1, 0.99 (0.98, 1.00); rater 2, 0.98 (0.96, 0.99). Inter-rater agreement was substantial for T 2 -FLAIR (κ = 0.68) and FLAIR* (κ = 0.74), despite low agreement on the 40% rule (κ = 0.47) ([Formula: see text] in all cases).
Conclusions: Joint clinical evaluation of T 2 -FLAIR and FLAIR* images modestly improves diagnostic accuracy for MS and does not require counting lesions with central veins.
(© The Author(s), 2016.)
References: Neuroimage. 2008 Feb 15;39(4):1682-92. (PMID: 18096412)
Neuroradiology. 2011 May;53(5):311-7. (PMID: 20585764)
Invest Radiol. 2009 Sep;44(9):491-4. (PMID: 19652606)
Radiology. 2012 Dec;265(3):926-32. (PMID: 23074257)
Eur J Radiol. 2013 May;82(5):719-27. (PMID: 22138119)
Mult Scler. 2013 Jul;19(8):1068-73. (PMID: 23246799)
Eur Radiol. 2013 Jul;23(7):1956-62. (PMID: 23436147)
Neurology. 2008 May 27;70(22):2076-8. (PMID: 18505982)
Ann Neurol. 2011 Feb;69(2):292-302. (PMID: 21387374)
Ann Neurol. 2013 Nov;74(5):669-78. (PMID: 23813441)
Nat Rev Neurol. 2015 Aug;11(8):471-82. (PMID: 26149978)
Mult Scler. 2014 Oct;20(11):1464-70. (PMID: 24639479)
Neuroinformatics. 2010 Mar;8(1):5-17. (PMID: 20077162)
Neurology. 2011 Feb 8;76(6):534-9. (PMID: 21300968)
Mult Scler. 2013 Mar;19(3):316-25. (PMID: 22736752)
AJNR Am J Neuroradiol. 2000 Jun-Jul;21(6):1039-42. (PMID: 10871010)
Neurology. 2013 Jan 8;80(2):145-51. (PMID: 23255828)
Neuroimage. 2011 Jun 15;56(4):1982-92. (PMID: 21458576)
Neurology. 2012 Aug 14;79(7):708-14. (PMID: 22855861)
Mult Scler. 2012 Nov;18(11):1592-9. (PMID: 22711711)
JAMA Neurol. 2013 May;70(5):623-8. (PMID: 23529352)
Eur Radiol. 2014 Apr;24(4):841-9. (PMID: 24317461)
Mult Scler. 2014 Mar;20(3):349-55. (PMID: 23836876)
معلومات مُعتمدة: T32 AG000247 United States AG NIA NIH HHS; Z99 NS999999 United States Intramural NIH HHS; ZIA NS003119-06 United States Intramural NIH HHS
فهرسة مساهمة: Keywords: MRI; central veins; diagnosis; multiple sclerosis
تواريخ الأحداث: Date Created: 20160116 Date Completed: 20180126 Latest Revision: 20191008
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4945460
DOI: 10.1177/1352458515624975
PMID: 26769065
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-0970
DOI:10.1177/1352458515624975