دورية أكاديمية
أعرض في EDS

C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection.

التفاصيل البيبلوغرافية
العنوان: C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection.
المؤلفون: Haque M; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Song J; Institutes of Irradiation/Immunology, The Third Military Medical University, Chongqing, People's Republic of China., Fino K; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Wang Y; Institutes of Irradiation/Immunology, The Third Military Medical University, Chongqing, People's Republic of China., Sandhu P; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Song X; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Norbury C; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Ni B; Institutes of Irradiation/Immunology, The Third Military Medical University, Chongqing, People's Republic of China., Fang D; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Salek-Ardakani S; Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Song J; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA jus35@psu.edu.
المصدر: Open biology [Open Biol] 2016 Jan; Vol. 6 (1), pp. 150208.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Royal Society Pub Country of Publication: England NLM ID: 101580419 Publication Model: Print Cited Medium: Internet ISSN: 2046-2441 (Electronic) Linking ISSN: 20462441 NLM ISO Abbreviation: Open Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Royal Society Pub., [2011]-
مواضيع طبية MeSH: Immunologic Memory*/genetics , Signal Transduction*, CD8-Positive T-Lymphocytes/*immunology , Proto-Oncogene Proteins c-myc/*metabolism , Virus Diseases/*immunology, Animals ; CD28 Antigens/metabolism ; Gene Expression Regulation ; I-kappa B Kinase/metabolism ; Immunity ; Inhibitor of Apoptosis Proteins/metabolism ; Mice, Transgenic ; NF-kappa B/metabolism ; Receptors, OX40 ; Repressor Proteins/metabolism ; Survivin ; Transcription, Genetic ; bcl-X Protein/metabolism
مستخلص: The signalling mechanisms of costimulation in the development of memory T cells remain to be clarified. Here, we show that the transcription factor c-Myc in CD8(+) T cells is controlled by costimulatory molecules, which modulates the development of memory CD8(+) T cells. C-Myc expression was dramatically reduced in Cd28(-/-) or Ox40(-/-) memory CD8(+) T cells, and c-Myc over-expression substantially reversed the defects in the development of T-cell memory following viral infection. C-Myc regulated the expression of survivin, an inhibitor of apoptosis, which promoted the generation of virus-specific memory CD8(+) T cells. Moreover, over-expression of survivin with bcl-xL, a downstream molecule of NF-κB and intracellular target of costimulation that controls survival, in Cd28(-/-) or Ox40(-/-) CD8(+) T cells, reversed the defects in the generation of memory T cells in response to viral infection. These results identify c-Myc as a key controller of memory CD8(+) T cells from costimulatory signals.
(© 2016 The Authors.)
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معلومات مُعتمدة: R01 AI079056 United States AI NIAID NIH HHS; R21 AI109239 United States AI NIAID NIH HHS; K18CA151798 United States CA NCI NIH HHS; R21AI109239 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: CD8+ T cells; c-Myc; costimulation; memory; viral infection
المشرفين على المادة: 0 (Birc5 protein, mouse)
0 (CD28 Antigens)
0 (Inhibitor of Apoptosis Proteins)
0 (NF-kappa B)
0 (Proto-Oncogene Proteins c-myc)
0 (Receptors, OX40)
0 (Repressor Proteins)
0 (Survivin)
0 (Tnfrsf4 protein, mouse)
0 (bcl-X Protein)
EC 2.7.11.10 (I-kappa B Kinase)
تواريخ الأحداث: Date Created: 20160122 Date Completed: 20161007 Latest Revision: 20181202
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4736826
DOI: 10.1098/rsob.150208
PMID: 26791245
قاعدة البيانات: MEDLINE
الوصف
تدمد:2046-2441
DOI:10.1098/rsob.150208