دورية أكاديمية
C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection.
العنوان: | C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. |
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المؤلفون: | Haque M; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Song J; Institutes of Irradiation/Immunology, The Third Military Medical University, Chongqing, People's Republic of China., Fino K; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Wang Y; Institutes of Irradiation/Immunology, The Third Military Medical University, Chongqing, People's Republic of China., Sandhu P; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Song X; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Norbury C; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Ni B; Institutes of Irradiation/Immunology, The Third Military Medical University, Chongqing, People's Republic of China., Fang D; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Salek-Ardakani S; Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Song J; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA jus35@psu.edu. |
المصدر: | Open biology [Open Biol] 2016 Jan; Vol. 6 (1), pp. 150208. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Royal Society Pub Country of Publication: England NLM ID: 101580419 Publication Model: Print Cited Medium: Internet ISSN: 2046-2441 (Electronic) Linking ISSN: 20462441 NLM ISO Abbreviation: Open Biol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Royal Society Pub., [2011]- |
مواضيع طبية MeSH: | Immunologic Memory*/genetics , Signal Transduction*, CD8-Positive T-Lymphocytes/*immunology , Proto-Oncogene Proteins c-myc/*metabolism , Virus Diseases/*immunology, Animals ; CD28 Antigens/metabolism ; Gene Expression Regulation ; I-kappa B Kinase/metabolism ; Immunity ; Inhibitor of Apoptosis Proteins/metabolism ; Mice, Transgenic ; NF-kappa B/metabolism ; Receptors, OX40 ; Repressor Proteins/metabolism ; Survivin ; Transcription, Genetic ; bcl-X Protein/metabolism |
مستخلص: | The signalling mechanisms of costimulation in the development of memory T cells remain to be clarified. Here, we show that the transcription factor c-Myc in CD8(+) T cells is controlled by costimulatory molecules, which modulates the development of memory CD8(+) T cells. C-Myc expression was dramatically reduced in Cd28(-/-) or Ox40(-/-) memory CD8(+) T cells, and c-Myc over-expression substantially reversed the defects in the development of T-cell memory following viral infection. C-Myc regulated the expression of survivin, an inhibitor of apoptosis, which promoted the generation of virus-specific memory CD8(+) T cells. Moreover, over-expression of survivin with bcl-xL, a downstream molecule of NF-κB and intracellular target of costimulation that controls survival, in Cd28(-/-) or Ox40(-/-) CD8(+) T cells, reversed the defects in the generation of memory T cells in response to viral infection. These results identify c-Myc as a key controller of memory CD8(+) T cells from costimulatory signals. (© 2016 The Authors.) |
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معلومات مُعتمدة: | R01 AI079056 United States AI NIAID NIH HHS; R21 AI109239 United States AI NIAID NIH HHS; K18CA151798 United States CA NCI NIH HHS; R21AI109239 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: CD8+ T cells; c-Myc; costimulation; memory; viral infection |
المشرفين على المادة: | 0 (Birc5 protein, mouse) 0 (CD28 Antigens) 0 (Inhibitor of Apoptosis Proteins) 0 (NF-kappa B) 0 (Proto-Oncogene Proteins c-myc) 0 (Receptors, OX40) 0 (Repressor Proteins) 0 (Survivin) 0 (Tnfrsf4 protein, mouse) 0 (bcl-X Protein) EC 2.7.11.10 (I-kappa B Kinase) |
تواريخ الأحداث: | Date Created: 20160122 Date Completed: 20161007 Latest Revision: 20181202 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC4736826 |
DOI: | 10.1098/rsob.150208 |
PMID: | 26791245 |
قاعدة البيانات: | MEDLINE |
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