التفاصيل البيبلوغرافية
العنوان: |
Quantification of intra-fraction motion in breast radiotherapy using supine magnetic resonance imaging. |
المؤلفون: |
van Heijst TC, Philippens ME, Charaghvandi RK, den Hartogh MD, Lagendijk JJ, van den Bongard HJ, van Asselen B |
المصدر: |
Physics in medicine and biology [Phys Med Biol] 2016 Feb 07; Vol. 61 (3), pp. 1352-70. |
نوع المنشور: |
Journal Article |
اللغة: |
English |
بيانات الدورية: |
Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Print Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE |
أسماء مطبوعة: |
Original Publication: Bristol : IOP Publishing |
مواضيع طبية MeSH: |
Algorithms* , Motion*, Breast Neoplasms/*radiotherapy , Magnetic Resonance Imaging/*methods , Radiotherapy, Computer-Assisted/*methods, Adult ; Aged ; Female ; Humans ; Middle Aged ; Supine Position |
مستخلص: |
In early-stage breast-cancer patients, accelerated partial-breast irradiation techniques (APBI) and hypofractionation are increasingly implemented after breast-conserving surgery (BCS). For a safe and effective radiation therapy (RT), the influence of intra-fraction motion during dose delivery becomes more important as associated fraction durations increase and targets become smaller. Current image-guidance techniques are insufficient to characterize local target movement in high temporal and spatial resolution for extended durations. Magnetic resonance imaging (MRI) can provide high soft-tissue contrast, allow fast imaging, and acquire images during longer periods. The goal of this study was to quantify intra-fraction motion using MRI scans from 21 breast-cancer patients, before and after BCS, in supine RT position, on two time scales. High-temporal 2-dimensional (2D) MRI scans (cine-MRI), acquired every 0.3 s during 2 min, and three 3D MRI scans, acquired over 20 min, were performed. The tumor (bed) and whole breast were delineated on 3D scans and delineations were transferred to the cine-MRI series. Consecutive scans were rigidly registered and delineations were transformed accordingly. Motion in sub-second time-scale (derived from cine-MRI) was generally regular and limited to a median of 2 mm. Infrequently, large deviations were observed, induced by deep inspiration, but these were temporary. Movement on multi-minute scale (derived from 3D MRI) varied more, although medians were restricted to 2.2 mm or lower. Large whole-body displacements (up to 14 mm over 19 min) were sparsely observed. The impact of motion on standard RT techniques is likely small. However, in novel hypofractionated APBI techniques, whole-body shifts may affect adequate RT delivery, given the increasing fraction durations and smaller targets. Motion management may thus be required. For this, on-line MRI guidance could be provided by a hybrid MRI/RT modality, such as the University Medical Center Utrecht MRI linear accelerator. |
تواريخ الأحداث: |
Date Created: 20160123 Date Completed: 20161005 Latest Revision: 20220316 |
رمز التحديث: |
20231215 |
DOI: |
10.1088/0031-9155/61/3/1352 |
PMID: |
26797074 |
قاعدة البيانات: |
MEDLINE |