دورية أكاديمية
Testicular effects of 3-nitro-1,2,4-triazol-5-one (NTO) in mice when exposed orally.
| العنوان: | Testicular effects of 3-nitro-1,2,4-triazol-5-one (NTO) in mice when exposed orally. |
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| المؤلفون: | Mullins AB; a Veterinary Services Program, Walter Reed Army Institute of Research/Naval Medical Research Center , Silver Spring , MD , USA and., Despain KE; a Veterinary Services Program, Walter Reed Army Institute of Research/Naval Medical Research Center , Silver Spring , MD , USA and., Wallace SM; a Veterinary Services Program, Walter Reed Army Institute of Research/Naval Medical Research Center , Silver Spring , MD , USA and., Honnold CL; a Veterinary Services Program, Walter Reed Army Institute of Research/Naval Medical Research Center , Silver Spring , MD , USA and., May Lent E; b U.S. Army Public Health Command, Army Institute of Public Health , Aberdeen Proving Ground , MD , USA. |
| المصدر: | Toxicology mechanisms and methods [Toxicol Mech Methods] 2016 Feb; Vol. 26 (2), pp. 97-103. Date of Electronic Publication: 2016 Jan 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6524 (Electronic) Linking ISSN: 15376516 NLM ISO Abbreviation: Toxicol Mech Methods Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London : Taylor and Francis, c2002- |
| مواضيع طبية MeSH: | Explosive Agents/*toxicity , Nitro Compounds/*toxicity , Spermatids/*drug effects , Testis/*drug effects , Triazoles/*toxicity, Administration, Oral ; Animals ; Dose-Response Relationship, Drug ; Epididymis/drug effects ; Epididymis/pathology ; Giant Cells/drug effects ; Giant Cells/pathology ; Male ; Mice, Inbred BALB C ; Spermatids/pathology ; Testis/pathology ; Time Factors |
| مستخلص: | 3-Nitro-1,2,4-triazol-5-one (NTO) is currently being investigated in the development of insensitive munitions. Rats orally exposed to NTO have demonstrated testicular toxicity in both subacute and subchronic studies; however, toxicity has not been verified in mice. Also, previous studies have not demonstrated the nature of NTO-induced testicular toxicity due to the prolonged dosing regimen utilized and effects of maturation depletion. In this study, a time-course design was used and the earliest pathological changes in testes of adult BALB/c mice orally dosed with NTO in corn oil suspensions at 0, 500 or 1000 mg/kg-day NTO for 1, 3, 7 or 14 d were evaluated. The earliest NTO-induced testicular changes occurred in the 1000 mg/kg-day group at day 7 and the 500 mg/kg-day group at day 14 as evident by the presence of bi- and multinucleated giant cells (MNGCs) of almost all spermatids in an isolated stage II-III tubule/step 2-3 and a stage IX tubule/step 9 in the 1000 and 500 mg/kg-day groups, respectively. Testicular toxicity was characterized by degeneration and the presence of bi- and MNGCs of spermatids (stages II-III and IX), which progressed to additional germ cell degeneration as dosing duration increased. Occasional step 16 spermatid retention was also noted in stage XII and I tubules in the day 14, 1000 mg/kg-day group. These data indicate that NTO is a testicular toxicant in mice and that spermatids are the most sensitive cell. The presence of retained spermatids warrants further investigation regarding NTO's role as a direct Sertoli cell toxicant. |
| فهرسة مساهمة: | Keywords: 932-64-9; BALB/c; IMX 101; degeneration; insensitive munitions; mice; testicular effects |
| المشرفين على المادة: | 0 (3-nitro-1,2,4-triazol-5-one) 0 (Explosive Agents) 0 (Nitro Compounds) 0 (Triazoles) |
| تواريخ الأحداث: | Date Created: 20160126 Date Completed: 20170320 Latest Revision: 20170320 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3109/15376516.2015.1118175 |
| PMID: | 26804465 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1537-6524 |
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| DOI: | 10.3109/15376516.2015.1118175 |