دورية أكاديمية
أعرض في EDS

Plasma Vasoprotective Eicosanoid Concentrations in Healthy Greyhounds and Non-Greyhound Dogs.

التفاصيل البيبلوغرافية
العنوان: Plasma Vasoprotective Eicosanoid Concentrations in Healthy Greyhounds and Non-Greyhound Dogs.
المؤلفون: Martinez JT; Department of Veterinary Biosciences, Ohio State University College of Veterinary Medicine, Columbus, OH., Rogers LK; Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH., Kellogg C; Department of Veterinary Clinical Sciences, Ohio State University College of Veterinary Medicine, Columbus, OH., Iazbik MC; Veterinary Medical Center, Columbus, OH., Couto CG; Department of Veterinary Clinical Sciences, Ohio State University College of Veterinary Medicine, Columbus, OH., Pressler BM; Department of Veterinary Clinical Sciences, Ohio State University College of Veterinary Medicine, Columbus, OH., Hoepf TM; Department of Veterinary Biosciences, Ohio State University College of Veterinary Medicine, Columbus, OH., Radin MJ; Department of Veterinary Biosciences, Ohio State University College of Veterinary Medicine, Columbus, OH.
المصدر: Journal of veterinary internal medicine [J Vet Intern Med] 2016 Mar-Apr; Vol. 30 (2), pp. 583-90. Date of Electronic Publication: 2016 Jan 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Periodicals Country of Publication: United States NLM ID: 8708660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-1676 (Electronic) Linking ISSN: 08916640 NLM ISO Abbreviation: J Vet Intern Med Subsets: MEDLINE
أسماء مطبوعة: Publication: <2010-> : Malden, MA : Wiley Periodicals
Original Publication: Philadelphia : J.B. Lippincott Co., [c1987-
مواضيع طبية MeSH: Dogs/*blood , Eicosanoids/*blood, Animals ; Dogs/genetics ; Eicosanoids/genetics ; Prospective Studies
مستخلص: Background: Hypertension and albuminuria often coexist in Greyhounds, suggesting generalized vascular dysfunction that could contribute to the development of a variety of diseases in this breed. Eicosanoid metabolites of arachidonic acid (AA) mediate endothelial function, vascular reactivity, and proteinuria in humans and in rodent models.
Hypothesis: The eicosanoid profile of Greyhounds is shifted toward metabolites that promote vascular dysfunction, hypertension, and proteinuria.
Animals: Healthy Greyhounds (n = 20) and non-Greyhound (n = 20) dogs that were consecutively enrolled in a blood donor program.
Methods: Prospective study. Plasma eicosanoid metabolites were assayed by liquid chromatography/electrospray ionization mass spectrometry (LC/ESI/MS) and compared to systolic blood pressure (SP) measurements and urine albumin concentration.
Results: Isomers of hydroxyeicosatetraenoic acid (HETE) were higher in Greyhounds than non-Greyhounds (median, range in pmol/mL: 5(S)HETE 19.82, 8.55-32.95 versus 13.54, 4.33-26.27, P = .033; 8(S)HETE 9.39, 3.28-19.84 versus 5.80, 2.25-17.66, P = .002; 9(S)HETE 9.46, 2.43-13.79 versus 5.82, 1.50-17.16, P = .026; 12(S)HETE 10.17, 3.81-40.06 versus 7.24, 2.9-16.16, P = .022). Dihydroxyeicosatrienoic acid (DHET) isomers also were higher in Greyhounds compared to non-Greyhounds (mean ± SD in pmol/mL: 8,9DHET 5.78 ± 2.13 versus 4.03 ± 1.36, P = .004; 11,12DHET 11.98 ± 2.86 versus 8.90 ± 3.48, P = .004; 14,15DHET 7.23 ± 2.19 versus 5.76 ± 1.87, P = .028). Albuminuria correlated with total DHET (rs = 0.46, P = .003). SP was positively correlated with 11,12EET (rs = 0.42, P = .006) and 20(S)HETE (rs = 0.38, P = .017). SP and 8,9EET were inversely correlated (rs = -0.49, P = .001).
Conclusions and Clinical Importance: Plasma eicosanoid profile in Greyhounds was consistent with activation of metabolic pathways known to promote vascular dysfunction and might contribute to higher blood pressures and albuminuria. Inhibition of these eicosanoid pathways should be evaluated as therapeutic targets in Greyhounds.
(Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)
References: J Am Vet Med Assoc. 2003 Feb 1;222(3):322-9. (PMID: 12564594)
Hypertension. 2005 Oct;46(4):975-81. (PMID: 16157792)
Drug Metab Dispos. 1999 Nov;27(11):1293-9. (PMID: 10534314)
J Vet Intern Med. 2008 May-Jun;22(3):525-33. (PMID: 18466249)
Cancer Metastasis Rev. 2011 Dec;30(3-4):277-94. (PMID: 22002716)
Int J Nephrol Renovasc Dis. 2013 Dec 21;7:13-24. (PMID: 24379690)
J Vet Intern Med. 2011 Jul-Aug;25(4):861-5. (PMID: 21615497)
Xenobiotica. 2000 Jun;30(6):575-88. (PMID: 10923860)
Anat Rec. 1964 Jun;149:173-9. (PMID: 14173791)
Vet Pathol. 1988 Nov;25(6):401-7. (PMID: 3212884)
Am J Physiol Renal Physiol. 2009 Sep;297(3):F740-8. (PMID: 19553349)
Am J Vet Res. 1992 Jun;53(6):1027-32. (PMID: 1626771)
J Vet Intern Med. 2012 Nov-Dec;26(6):1320-9. (PMID: 23083217)
Biochim Biophys Acta. 2015 Apr;1851(4):340-55. (PMID: 25449650)
J Vet Intern Med. 2004 May-Jun;18(3):289-94. (PMID: 15188813)
Nephrol Dial Transplant. 2012 Jul;27(7):2673-85. (PMID: 22802583)
J Am Soc Nephrol. 2006 Aug;17(8):2120-6. (PMID: 16825331)
Am J Physiol. 1991 Aug;261(2 Pt 2):H451-6. (PMID: 1908641)
Vet Rec. 2008 Feb 2;162(5):141-7. (PMID: 18245745)
Free Radic Biol Med. 2006 Dec 1;41(11):1678-83. (PMID: 17145556)
Am J Physiol. 1976 Jan;230(1):211-8. (PMID: 1251905)
Vet Clin Pathol. 2010 Jun;39(2):203-9. (PMID: 20059754)
J Vet Intern Med. 2007 May-Jun;21(3):542-58. (PMID: 17552466)
Am J Physiol. 1991 Oct;261(4 Pt 1):C623-33. (PMID: 1928326)
Am J Physiol Regul Integr Comp Physiol. 2012 Feb 1;302(3):R321-30. (PMID: 22116511)
J Vet Pharmacol Ther. 2007 Aug;30(4):314-9. (PMID: 17610404)
J Small Anim Pract. 2005 Oct;46(10):469-78. (PMID: 16245660)
Infect Immun. 2010 Jun;78(6):2454-65. (PMID: 20351145)
Basic Res Cardiol. 1986 Jul-Aug;81(4):417-24. (PMID: 2946286)
J Small Anim Pract. 1999 Jan;40(1):3-6. (PMID: 10092034)
J Biol Chem. 2011 Jun 24;286(25):22478-88. (PMID: 21536676)
Kidney Int. 2001 Sep;60(3):1026-36. (PMID: 11532097)
J Clin Hypertens (Greenwich). 2007 Mar;9(3):196-200. (PMID: 17341995)
J Am Soc Nephrol. 2004 May;15(5):1244-53. (PMID: 15100364)
J Am Vet Med Assoc. 2014 Jul 1;245(1):113-7. (PMID: 24941395)
Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:2-7. (PMID: 23333581)
J Vet Intern Med. 2007 Nov-Dec;21(6):1243-50. (PMID: 18196733)
J Clin Endocrinol Metab. 1996 May;81(5):1940-5. (PMID: 8626861)
J Biol Chem. 2002 Mar 22;277(12 ):9920-8. (PMID: 11786549)
Vet Pathol. 1995 Sep;32(5):451-9. (PMID: 8578634)
Clin Sci (Lond). 2007 Jun;112(7):375-84. (PMID: 17324119)
Kidney Blood Press Res. 1998;21(1):13-21. (PMID: 9661132)
Prog Lipid Res. 2004 Jan;43(1):55-90. (PMID: 14636671)
J Pharmacol Exp Ther. 2001 Feb;296(2):293-305. (PMID: 11160610)
Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:235-43. (PMID: 12432921)
Cell Mol Life Sci. 2002 May;59(5):799-807. (PMID: 12088280)
Toxicol Appl Pharmacol. 2013 Nov 15;273(1):47-57. (PMID: 23993975)
فهرسة مساهمة: Keywords: Arachidonic acid; Cytochrome P450; Hypertension; Microalbuminuria
المشرفين على المادة: 0 (Eicosanoids)
تواريخ الأحداث: Date Created: 20160126 Date Completed: 20161222 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4913591
DOI: 10.1111/jvim.13833
PMID: 26806473
قاعدة البيانات: MEDLINE
الوصف
تدمد:1939-1676
DOI:10.1111/jvim.13833