دورية أكاديمية
أعرض في EDS

Amyloid deposition in semantic dementia: a positron emission tomography study.

التفاصيل البيبلوغرافية
العنوان: Amyloid deposition in semantic dementia: a positron emission tomography study.
المؤلفون: Brown EE; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Graff-Guerrero A; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada., Houle S; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada., Mizrahi R; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada., Wilson AA; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada., Pollock BG; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada., Mulsant BH; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada., Felsky D; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Voineskos AN; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada., Tang-Wai DF; University Health Network, Toronto, Ontario, Canada., Verhoeff NP; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Baycrest Health Sciences, Toronto, Ontario, Canada., Freedman M; Baycrest Health Sciences, Toronto, Ontario, Canada.; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, Division of Neurology, Mt. Sinai Hospital, Toronto, Ontario, Canada., Ismail Z; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada.; Departments of Psychiatry and Neurology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada., Chow TW; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada.; Baycrest Health Sciences, Toronto, Ontario, Canada.; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
المصدر: International journal of geriatric psychiatry [Int J Geriatr Psychiatry] 2016 Sep; Vol. 31 (9), pp. 1064-74. Date of Electronic Publication: 2016 Jan 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley Country of Publication: England NLM ID: 8710629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1166 (Electronic) Linking ISSN: 08856230 NLM ISO Abbreviation: Int J Geriatr Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: Chichester : John Wiley
Original Publication: Chichester, Sussex, England ; [New York] : Wiley, c1986-
مواضيع طبية MeSH: Alzheimer Disease/*metabolism , Amyloid beta-Peptides/*metabolism , Cerebral Cortex/*metabolism , Frontotemporal Dementia/*metabolism, Aged ; Aniline Compounds ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Neurodegenerative Diseases/metabolism ; Positron-Emission Tomography/methods ; Thiazoles
مستخلص: Background: Pittsburgh compound B ([11C]-PIB) identifies amyloid-β (Aβ) deposition in vivo. Asymptomatic Aβ deposition has been reported consistently in some healthy older subjects. Of patients with frontotemporal dementia, those who have later onset have a higher potential for Aβ deposition.
Objective: Comparison of Aβ deposition in Alzheimer's disease (AD), healthy older controls, and patients with early- and late-onset semantic dementia (SD), a subtype of frontotemporal dementia.
Methods: Subjects were recruited from tertiary academic care centers specializing in assessment and management of patients with neurodegenerative disease. We used the radiotracer [11C]-PIB in a high-resolution positron emission tomography scanner to evaluate 11 participants with SD (six with onset before age 65 and five with later onset), 9 with probable AD, and 10 controls over age 60. The main outcome measures were frontal, temporal, parietal, and total [11C]-PIB standardized uptake value ratios to establish PIB-positive (PIB+) cutoff.
Results: The five patients with late-onset SD were PIB-negative. Two of six with early-onset SD, seven of nine with AD, and 1 of 10 controls were PIB+. The SD participants who were PIB+ did not have memory or visuospatial deficits that are typical in AD.
Conclusions: Aβ deposition does not seem to be associated with late-onset SD. Future larger studies might confirm whether a significant minority of early-onset SD patients exhibit Aβ deposition. Copyright © 2016 John Wiley & Sons, Ltd.
(Copyright © 2016 John Wiley & Sons, Ltd.)
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معلومات مُعتمدة: R03 AG034413 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Alzheimer disease; Pittsburgh compound B; amyloid; frontotemporal dementia; positron emission tomography; semantic dementia
المشرفين على المادة: 0 (2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole)
0 (Amyloid beta-Peptides)
0 (Aniline Compounds)
0 (Thiazoles)
تواريخ الأحداث: Date Created: 20160126 Date Completed: 20180221 Latest Revision: 20210109
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6139433
DOI: 10.1002/gps.4423
PMID: 26807731
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-1166
DOI:10.1002/gps.4423