دورية أكاديمية
أعرض في EDS

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.

التفاصيل البيبلوغرافية
العنوان: Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.
المؤلفون: Oudin MJ; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Jonas O; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Kosciuk T; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Broye LC; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Guido BC; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Wyckoff J; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Riquelme D; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Lamar JM; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Asokan SB; Lineberger Comprehensive Cancer Center, UNC Chapel Hill, Chapel Hill, North Carolina., Whittaker C; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Ma D; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Langer R; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Cima MJ; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts., Wisinski KB; Department of Medicine, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin., Hynes RO; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts. Department of Biology, MIT, Cambridge, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland., Lauffenburger DA; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts. Department of Biological Engineering, MIT, Cambridge, Massachusetts., Keely PJ; Department of Cell and Regenerative Biology, University of Wisconsin Madison, Madison, Wisconsin., Bear JE; Lineberger Comprehensive Cancer Center, UNC Chapel Hill, Chapel Hill, North Carolina. Howard Hughes Medical Institute, Chevy Chase, Maryland., Gertler FB; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts. Department of Biology, MIT, Cambridge, Massachusetts. fgertler@mit.edu.
المصدر: Cancer discovery [Cancer Discov] 2016 May; Vol. 6 (5), pp. 516-31. Date of Electronic Publication: 2016 Jan 25.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : American Association for Cancer Research
مواضيع طبية MeSH: Cell Movement*, Extracellular Matrix/*metabolism , Neoplasms/*metabolism , Neoplasms/*pathology, Actins/metabolism ; Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Collagen/genetics ; Collagen/metabolism ; Disease Models, Animal ; Disease Progression ; Extracellular Matrix/genetics ; Female ; Fibronectins/genetics ; Fibronectins/metabolism ; Gene Expression ; Heterografts ; Humans ; Integrin alpha5beta1/metabolism ; Kaplan-Meier Estimate ; Mice ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Neoplasm Metastasis ; Neoplasms/genetics ; Neoplasms/mortality ; Prognosis ; Protein Binding ; Signal Transduction ; Tumor Microenvironment
مستخلص: Unlabelled: Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here, we show that FN gradients elicit directional movement of breast cancer cells, in vitro and in vivo Haptotaxis on FN gradients requires direct interaction between α5β1 integrin and MENA, an actin regulator, and involves increases in focal complex signaling and tumor cell-mediated extracellular matrix (ECM) remodeling. Compared with MENA, higher levels of the prometastatic MENA(INV) isoform associate with α5, which enables 3-D haptotaxis of tumor cells toward the high FN concentrations typically present in perivascular space and in the periphery of breast tumor tissue. MENA(INV) and FN levels were correlated in two breast cancer cohorts, and high levels of MENA(INV) were significantly associated with increased tumor recurrence as well as decreased patient survival. Our results identify a novel tumor cell-intrinsic mechanism that promotes metastasis through ECM remodeling and ECM-guided directional migration.
Significance: Here, we provide new insight into how tumor cell:ECM interactions generate signals and structures that promote directed tumor cell migration, a critical component of metastasis. Our results identify a tumor cell-intrinsic mechanism driven by the actin regulatory protein MENA that promotes ECM remodeling and haptotaxis along FN gradients. Cancer Discov; 6(5); 516-31. ©2016 AACR.See related commentary by Santiago-Medina and Yang, p. 474This article is highlighted in the In This Issue feature, p. 461.
(©2016 American Association for Cancer Research.)
التعليقات: Comment in: Cancer Discov. 2016 May;6(5):474-6. (PMID: 27138561)
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معلومات مُعتمدة: R01 CA114462 United States CA NCI NIH HHS; R01 CA142833 United States CA NCI NIH HHS; P30 CA016086 United States CA NCI NIH HHS; P30 CA014051 United States CA NCI NIH HHS; U54 CA112967 United States CA NCI NIH HHS; U54 CA163109 United States CA NCI NIH HHS; U01 CA184897 United States CA NCI NIH HHS; U01 CA143069 United States CA NCI NIH HHS; R01 GM110155 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Actins)
0 (Enah protein, human)
0 (Fibronectins)
0 (Integrin alpha5beta1)
0 (Microfilament Proteins)
9007-34-5 (Collagen)
تواريخ الأحداث: Date Created: 20160127 Date Completed: 20170418 Latest Revision: 20220310
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4854754
DOI: 10.1158/2159-8290.CD-15-1183
PMID: 26811325
قاعدة البيانات: MEDLINE
الوصف
تدمد:2159-8290
DOI:10.1158/2159-8290.CD-15-1183