دورية أكاديمية
أعرض في EDS

Muscle-type Identity of Proprioceptors Specified by Spatially Restricted Signals from Limb Mesenchyme.

التفاصيل البيبلوغرافية
العنوان: Muscle-type Identity of Proprioceptors Specified by Spatially Restricted Signals from Limb Mesenchyme.
المؤلفون: Poliak S; Department of Neuroscience, Biochemistry, and Molecular Biophysics, Columbia University, New York, NY 10032, USA., Norovich AL; Department of Biological Sciences, Columbia University, New York, NY 10032, USA., Yamagata M; Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA., Sanes JR; Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA., Jessell TM; Department of Neuroscience, Biochemistry, and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Howard Hughes Medical Institute, Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA. Electronic address: tmj1@columbia.edu.
المصدر: Cell [Cell] 2016 Jan 28; Vol. 164 (3), pp. 512-25.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, Ma : Cell Press
Original Publication: Cambridge, MIT Press.
مواضيع طبية MeSH: Proprioception*, Extremities/*embryology , Mesoderm/*metabolism, Animals ; Cadherins/genetics ; Calcium-Binding Proteins/genetics ; Embryo, Mammalian/metabolism ; Extremities/physiology ; Mice ; Muscle, Skeletal/innervation ; Neurons/metabolism ; Semaphorins/genetics ; Signal Transduction ; Transcriptome
مستخلص: The selectivity with which proprioceptive sensory neurons innervate their central and peripheral targets implies that they exhibit distinctions in muscle-type identity. The molecular correlates of proprioceptor identity and its origins remain largely unknown, however. In screens to define muscle-type proprioceptor character, we find all-or-none differences in gene expression for proprioceptors that control antagonistic muscles at a single hindlimb joint. Analysis of three of these genes, cadherin13 (cdh13), semaphorin5a (sema5a), and cartilage-acidic protein-1 (crtac1), reveals expression in proprioceptor subsets that supply muscle groups located at restricted dorsoventral and proximodistal domains of the limb. Genetically altering the dorsoventral character of the limb mesenchyme elicits a change in the profile of proprioceptor cdh13, sema5a, and crtac1 expression. These findings indicate that proprioceptors acquire aspects of their muscle-type identity in response to mesenchymal signals expressed in restricted proximodistal and dorsoventral domains of the developing limb.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 NS033245 United States NS NINDS NIH HHS; R01 EY022073 United States EY NEI NIH HHS; United States Howard Hughes Medical Institute; T32 GM008798 United States GM NIGMS NIH HHS; R01 NS080932 United States NS NINDS NIH HHS
المشرفين على المادة: 0 (Cadherins)
0 (Calcium-Binding Proteins)
0 (Crtac1 protein, mouse)
0 (H-cadherin)
0 (Sema5A protein, mouse)
0 (Semaphorins)
تواريخ الأحداث: Date Created: 20160130 Date Completed: 20160609 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4733250
DOI: 10.1016/j.cell.2015.12.049
PMID: 26824659
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4172
DOI:10.1016/j.cell.2015.12.049