دورية أكاديمية
Muscle-type Identity of Proprioceptors Specified by Spatially Restricted Signals from Limb Mesenchyme.
العنوان: | Muscle-type Identity of Proprioceptors Specified by Spatially Restricted Signals from Limb Mesenchyme. |
---|---|
المؤلفون: | Poliak S; Department of Neuroscience, Biochemistry, and Molecular Biophysics, Columbia University, New York, NY 10032, USA., Norovich AL; Department of Biological Sciences, Columbia University, New York, NY 10032, USA., Yamagata M; Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA., Sanes JR; Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA., Jessell TM; Department of Neuroscience, Biochemistry, and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Howard Hughes Medical Institute, Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA. Electronic address: tmj1@columbia.edu. |
المصدر: | Cell [Cell] 2016 Jan 28; Vol. 164 (3), pp. 512-25. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Cambridge, Ma : Cell Press Original Publication: Cambridge, MIT Press. |
مواضيع طبية MeSH: | Proprioception*, Extremities/*embryology , Mesoderm/*metabolism, Animals ; Cadherins/genetics ; Calcium-Binding Proteins/genetics ; Embryo, Mammalian/metabolism ; Extremities/physiology ; Mice ; Muscle, Skeletal/innervation ; Neurons/metabolism ; Semaphorins/genetics ; Signal Transduction ; Transcriptome |
مستخلص: | The selectivity with which proprioceptive sensory neurons innervate their central and peripheral targets implies that they exhibit distinctions in muscle-type identity. The molecular correlates of proprioceptor identity and its origins remain largely unknown, however. In screens to define muscle-type proprioceptor character, we find all-or-none differences in gene expression for proprioceptors that control antagonistic muscles at a single hindlimb joint. Analysis of three of these genes, cadherin13 (cdh13), semaphorin5a (sema5a), and cartilage-acidic protein-1 (crtac1), reveals expression in proprioceptor subsets that supply muscle groups located at restricted dorsoventral and proximodistal domains of the limb. Genetically altering the dorsoventral character of the limb mesenchyme elicits a change in the profile of proprioceptor cdh13, sema5a, and crtac1 expression. These findings indicate that proprioceptors acquire aspects of their muscle-type identity in response to mesenchymal signals expressed in restricted proximodistal and dorsoventral domains of the developing limb. (Copyright © 2016 Elsevier Inc. All rights reserved.) |
References: | Nat Neurosci. 2015 Jan;18(1):145-53. (PMID: 25420068) PLoS Biol. 2011 Feb;9(2):e1001020. (PMID: 21364975) Nat Neurosci. 2004 Aug;7(8):812-8. (PMID: 15247919) J Neurosci. 2007 Apr 4;27(14):3686-94. (PMID: 17409232) Cell. 2011 Oct 28;147(3):653-65. (PMID: 22036571) Neuron. 2013 Mar 20;77(6):1055-68. (PMID: 23522042) Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a001339. (PMID: 20066096) J Neurosci. 1990 Aug;10(8):2699-716. (PMID: 2167355) Cell Rep. 2013 Nov 14;5(3):748-58. (PMID: 24210822) Genesis. 2006 Aug;44(8):364-71. (PMID: 16850455) Neuron. 2015 Jul 1;87(1):111-23. (PMID: 26094608) Front Cell Neurosci. 2014 Oct 09;8:293. (PMID: 25346659) Elife. 2015;4. pii: e10841. doi: 10.7554/eLife.10841. (PMID: 26633881) J Neurosci. 1984 Oct;4(10):2518-27. (PMID: 6491720) J Physiol. 1957 Jun 18;137(1):22-50. (PMID: 13439582) Development. 1998 Mar;125(6):995-1004. (PMID: 9463346) J Morphol. 1979 Nov;162(2):275-309. (PMID: 537102) Development. 2002 Nov;129(21):4879-89. (PMID: 12397097) J Neurosci. 1997 May 1;17(9):3128-35. (PMID: 9096147) Dev Biol. 2002 Apr 15;244(2):305-18. (PMID: 11944939) Cell. 2009 Oct 2;139(1):161-74. (PMID: 19804761) PLoS One. 2014;9(1):e84823. (PMID: 24400119) J Neurosci. 1995 Dec;15(12):8191-8. (PMID: 8613753) Cell. 2014 Aug 14;158(4):793-807. (PMID: 25126785) Trends Neurosci. 2012 Jun;35(6):373-81. (PMID: 22516617) J Neurosci. 1991 May;11(5):1390-403. (PMID: 2027053) Dev Growth Differ. 2012 May;54(4):451-62. (PMID: 22417325) Acta Anat (Basel). 1994;151(1):1-13. (PMID: 7879588) Cell. 2013 Jul 18;154(2):351-64. (PMID: 23870124) Neuron. 2012 Jun 21;74(6):975-89. (PMID: 22726829) Dev Cell. 2003 Dec;5(6):937-44. (PMID: 14667415) |
معلومات مُعتمدة: | R01 NS033245 United States NS NINDS NIH HHS; R01 EY022073 United States EY NEI NIH HHS; United States Howard Hughes Medical Institute; T32 GM008798 United States GM NIGMS NIH HHS; R01 NS080932 United States NS NINDS NIH HHS |
المشرفين على المادة: | 0 (Cadherins) 0 (Calcium-Binding Proteins) 0 (Crtac1 protein, mouse) 0 (H-cadherin) 0 (Sema5A protein, mouse) 0 (Semaphorins) |
تواريخ الأحداث: | Date Created: 20160130 Date Completed: 20160609 Latest Revision: 20181113 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC4733250 |
DOI: | 10.1016/j.cell.2015.12.049 |
PMID: | 26824659 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1097-4172 |
---|---|
DOI: | 10.1016/j.cell.2015.12.049 |