دورية أكاديمية
أعرض في EDS

Recognition of genetic predisposition in pediatric cancer patients: An easy-to-use selection tool.

التفاصيل البيبلوغرافية
العنوان: Recognition of genetic predisposition in pediatric cancer patients: An easy-to-use selection tool.
المؤلفون: Jongmans MC; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. Electronic address: marjolijn.jongmans@radboudumc.nl., Loeffen JL; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands., Waanders E; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., Hoogerbrugge PM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Ligtenberg MJ; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., Kuiper RP; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., Hoogerbrugge N; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.
المصدر: European journal of medical genetics [Eur J Med Genet] 2016 Mar; Vol. 59 (3), pp. 116-25. Date of Electronic Publication: 2016 Jan 26.
نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101247089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0849 (Electronic) Linking ISSN: 17697212 NLM ISO Abbreviation: Eur J Med Genet Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier, c2005-
مواضيع طبية MeSH: Genetic Predisposition to Disease*, Neoplasms/*epidemiology , Neoplasms/*genetics, Abnormalities, Multiple/diagnosis ; Abnormalities, Multiple/epidemiology ; Abnormalities, Multiple/genetics ; Age Factors ; Child ; Child, Preschool ; Genetic Association Studies ; Humans ; Neoplasms/diagnosis ; Phenotype ; Population Surveillance/methods ; Risk ; Syndrome
مستخلص: Genetic predisposition for childhood cancer is under diagnosed. Identifying these patients may lead to therapy adjustments in case of syndrome-related increased toxicity or resistant disease and syndrome-specific screening programs may lead to early detection of a further independent malignancy. Cancer surveillance might also be warranted for affected relatives and detection of a genetic mutation can allow for reproductive counseling. Here we present an easy-to-use selection tool, based on a systematic review of pediatric cancer predisposing syndromes, to identify patients who may benefit from genetic counseling. The selection tool involves five questions concerning family history, the type of malignancy, multiple primary malignancies, specific features and excessive toxicity, which results in the selection of those patients that may benefit from referral to a clinical geneticist.
(Copyright © 2016 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
فهرسة مساهمة: Keywords: Cancer susceptibility; Childhood cancer; Congenital anomalies; Dysmorphisms; Family history; Selection tool
تواريخ الأحداث: Date Created: 20160131 Date Completed: 20161213 Latest Revision: 20220311
رمز التحديث: 20240628
DOI: 10.1016/j.ejmg.2016.01.008
PMID: 26825391
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-0849
DOI:10.1016/j.ejmg.2016.01.008