دورية أكاديمية
Prolonged warm ischemia time is associated with graft failure and mortality after kidney transplantation.
| العنوان: | Prolonged warm ischemia time is associated with graft failure and mortality after kidney transplantation. |
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| المؤلفون: | Tennankore KK; Department of Medicine (Division of Nephrology), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada. Electronic address: ktennankore@gmail.com., Kim SJ; Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada., Alwayn IP; Department of Surgery, Multi-Organ Transplant Program, Dalhousie University, Halifax, Nova Scotia, Canada., Kiberd BA; Department of Medicine (Division of Nephrology), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health Authority, Halifax, Nova Scotia, Canada. |
| المصدر: | Kidney international [Kidney Int] 2016 Mar; Vol. 89 (3), pp. 648-58. Date of Electronic Publication: 2015 Dec 30. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Graft Survival*, Kidney Transplantation/*adverse effects , Kidney Transplantation/*mortality , Postoperative Complications/*mortality , Warm Ischemia/*adverse effects , Warm Ischemia/*mortality, Adult ; Delayed Graft Function/etiology ; Delayed Graft Function/mortality ; Delayed Graft Function/therapy ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications/diagnosis ; Postoperative Complications/therapy ; Registries ; Renal Dialysis ; Reoperation ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; United States ; Young Adult |
| مستخلص: | Warm ischemia time is a potentially modifiable insult to transplanted kidneys, but little is known about its effect on long-term outcomes. Here we conducted a study of United States kidney transplant recipients (years 2000-2013) to determine the association between warm ischemia time (the time from organ removal from cold storage to reperfusion with warm blood) and death/graft failure. Times under 10 minutes were potentially attributed to coding error. Therefore, the 10-to-under-20-minute interval was chosen as the reference group. The primary outcome was mortality and graft failure (return to chronic dialysis or preemptive retransplantation) adjusted for recipient, donor, immunologic, and surgical factors. The study included 131,677 patients with 35,901 events. Relative to the reference patients, times of 10 to under 20, 20 to under 30, 30 to under 40, 40 to under 50, 50 to under 60, and 60 and more minutes were associated with hazard ratios of 1.07 (95% confidence interval, 0.99-1.15), 1.13 (1.06-1.22), 1.17 (1.09-1.26), 1.20 (1.12-1.30), and 1.23 (1.15-1.33) for the composite event, respectively. Association between prolonged warm ischemia time and death/graft failure persisted after stratification by donor type (living vs. deceased donor) and delayed graft function status. Thus, warm ischemia time is associated with adverse long-term patient and graft survival after kidney transplantation. Identifying strategies to reduce warm ischemia time is an important consideration for future study. (Copyright © 2015 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Kidney Int. 2016 Jul;90(1):226-7. (PMID: 27312452) Comment in: Kidney Int. 2016 Jul;90(1):227. (PMID: 27312454) |
| فهرسة مساهمة: | Keywords: graft failure; survival; transplantation; warm ischemia time |
| تواريخ الأحداث: | Date Created: 20160217 Date Completed: 20161213 Latest Revision: 20220318 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.kint.2015.09.002 |
| PMID: | 26880458 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1523-1755 |
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| DOI: | 10.1016/j.kint.2015.09.002 |