دورية أكاديمية
Of rodents and men: understanding the emergence of motor and cognitive symptoms in Huntington disease.
| العنوان: | Of rodents and men: understanding the emergence of motor and cognitive symptoms in Huntington disease. |
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| المؤلفون: | Abada YS; aBrain and Spine Institute (ICM), Team 'Alzheimer's and Prion Diseases', CNRS-UMR 7225 Pitié-Salpêtrière University Hospital, Paris, France bSchool of Psychology, Victoria University of Wellington, Wellington, New Zealand., Ellenbroek BA |
| المصدر: | Behavioural pharmacology [Behav Pharmacol] 2016 Aug; Vol. 27 (5), pp. 403-14. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams and Wilkins Country of Publication: England NLM ID: 9013016 Publication Model: Print Cited Medium: Internet ISSN: 1473-5849 (Electronic) Linking ISSN: 09558810 NLM ISO Abbreviation: Behav Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Lippincott Williams and Wilkins Original Publication: London : Clinical Neuroscience Publishers, |
| مواضيع طبية MeSH: | Disease Models, Animal*, Cognition Disorders/*etiology , Huntington Disease/*physiopathology, Animals ; Cognition Disorders/genetics ; Cognition Disorders/physiopathology ; Drug Evaluation, Preclinical/methods ; Endpoint Determination ; Humans ; Huntington Disease/genetics ; Mice ; Rats ; Species Specificity ; Translational Research, Biomedical/methods |
| مستخلص: | Arguably, one of the most important milestones in Huntington disease research since the discovery of the gene responsible has been the generation of different genetic animal models. Although clinical reports have shown evidence of progressive cognitive impairments in gene carriers before motor symptoms are diagnosed, such symptoms have been much less obvious in animal models. In this review, we summarize the three main classes of animal models for Huntington disease and describe some relevant translational assays for behavioural deficits evaluation. Finally, we argue that a good knowledge of the emergence of motor and cognitive symptoms in mice and rat models is indispensable for the selection of endpoint measures in early preclinical drug screening studies. |
| تواريخ الأحداث: | Date Created: 20160218 Date Completed: 20171108 Latest Revision: 20211204 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1097/FBP.0000000000000217 |
| PMID: | 26886208 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-5849 |
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| DOI: | 10.1097/FBP.0000000000000217 |