دورية أكاديمية
Response to Therapy With Teriparatide, Denosumab, or Both in Postmenopausal Women in the DATA (Denosumab and Teriparatide Administration) Study Randomized Controlled Trial.
| العنوان: | Response to Therapy With Teriparatide, Denosumab, or Both in Postmenopausal Women in the DATA (Denosumab and Teriparatide Administration) Study Randomized Controlled Trial. |
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| المؤلفون: | Leder BZ; Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA. Electronic address: bzleder@partners.org., Tsai JN; Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Neer RM; Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Uihlein AV; Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Wallace PM; Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Burnett-Bowie SA; Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA. |
| المصدر: | Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry [J Clin Densitom] 2016 Jul-Sep; Vol. 19 (3), pp. 346-51. Date of Electronic Publication: 2016 Feb 15. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9808212 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1094-6950 (Print) Linking ISSN: 10946950 NLM ISO Abbreviation: J Clin Densitom Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Totowa, NJ : Humana Press, c1998- |
| مواضيع طبية MeSH: | Bone Density Conservation Agents/*therapeutic use , Denosumab/*therapeutic use , Osteoporosis, Postmenopausal/*drug therapy , Teriparatide/*therapeutic use, Absorptiometry, Photon ; Aged ; Aged, 80 and over ; Bone Density ; Drug Therapy, Combination ; Female ; Femur Neck/diagnostic imaging ; Hip/diagnostic imaging ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Middle Aged ; Osteoporosis, Postmenopausal/diagnostic imaging ; Treatment Outcome |
| مستخلص: | Both antiresorptive and anabolic osteoporosis medications increase bone mineral density (BMD), but no single agent can restore normal bone strength in most osteoporotic patients. Moreover, the magnitude and consistency of the patient response to each individual agent vary depending on the anatomic site. In the DATA study, we reported that in postmenopausal osteoporotic women, 2 years of combined denosumab and teriparatide increase mean BMD at the hip and spine more than either drug alone. In the current analysis, we wished to determine if the individual rates of BMD response were also greater among women treated with both drugs. In DATA, 94 postmenopausal osteoporotic women (ages 51-91) were randomized to receive teriparatide (20 mcg subcutaneously daily), denosumab (60 mg subcutaneously every 6 mo), or both medications for 24 mo. The BMD of the total hip (TH), femoral neck (FN), and lumbar spine (LS) were assessed by dual-energy X-ray absorptiometry. The 82 subjects who completed all 2-yr treatments were analyzed. Responders were defined as experiencing BMD increases of >3%. An "excellent response" was defined as an increase of >6%. Over 24 mo, TH BMD increased by >3% in 36%, 53%, and 92% of women in the teriparatide, denosumab, and combination groups, respectively, and by >6% in 11%, 17%, and 50% in the teriparatide, denosumab, and combination groups, respectively (p < 0.01 for all comparisons vs combination). FN response rates were similar to TH. In the LS, BMD increased by >3% in 85%, 93%, and 100% of women in the teriparatide, denosumab, and combination groups, respectively (p = nonsignificant for all comparisons) and by >6% in 63%, 78%, and 100% of women in the teriparatide, denosumab, and combination groups, respectively (combination vs teriparatide, p = 0.001; combination vs denosumab, p = 0.016). In summary, more women treated with 24 mo of combined denosumab and teriparatide achieved a significant response at the TH and FN than those treated with either drug alone. All women treated with both agents together experienced an excellent response at the LS. These results support the continued investigation of combined denosumab and teriparatide therapy in postmenopausal osteoporotic women utilizing clinical endpoints such as fracture reduction. (Copyright © 2016 International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bone mineral density; combination therapy; denosumab; postmenopausal osteoporosis; teriparatide |
| المشرفين على المادة: | 0 (Bone Density Conservation Agents) 10T9CSU89I (Teriparatide) 4EQZ6YO2HI (Denosumab) |
| تواريخ الأحداث: | Date Created: 20160223 Date Completed: 20180205 Latest Revision: 20180830 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.jocd.2016.01.004 |
| PMID: | 26900146 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1094-6950 |
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| DOI: | 10.1016/j.jocd.2016.01.004 |