دورية أكاديمية
أعرض في EDS

Abnormal labyrinthine zone in the Hectd1-null placenta.

التفاصيل البيبلوغرافية
العنوان: Abnormal labyrinthine zone in the Hectd1-null placenta.
المؤلفون: Sarkar AA; Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA., Sabatino JA; Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA., Sugrue KF; Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA; Institute for Biomedical Sciences, The George Washington University, Washington, DC 20052, USA., Zohn IE; Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA; Institute for Biomedical Sciences, The George Washington University, Washington, DC 20052, USA. Electronic address: izohn@cnmcresearch.org.
المصدر: Placenta [Placenta] 2016 Feb; Vol. 38, pp. 16-23. Date of Electronic Publication: 2015 Dec 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8006349 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3102 (Electronic) Linking ISSN: 01434004 NLM ISO Abbreviation: Placenta Subsets: MEDLINE
أسماء مطبوعة: Publication: <2010- > : Amsterdam : Elsevier
Original Publication: London W.B. Saunders.
مواضيع طبية MeSH: Placenta/*metabolism , Placenta/*pathology , Placenta Diseases/*genetics , Placentation/*genetics , Ubiquitin-Protein Ligases/*genetics, Animals ; Female ; Giant Cells/physiology ; Mice ; Mice, Knockout ; Placenta/ultrastructure ; Placenta Diseases/metabolism ; Placenta Diseases/pathology ; Pregnancy ; Trophoblasts/metabolism ; Trophoblasts/pathology
مستخلص: Introduction: The labyrinthine zone of the placenta is where exchange of nutrients and waste occurs between maternal and fetal circulations. Proper development of the placental labyrinth is essential for successful growth of the developing fetus and abnormalities in placental development are associated with intrauterine growth restriction (IUGR), preeclampsia and fetal demise. Our previous studies demonstrate that Hectd1 is essential for development of the junctional and labyrinthine zones of the placenta. Here we further characterize labyrinthine zone defects in the Hectd1 mutant placenta.
Methods: The structure of the mutant placenta was compared to wildtype littermates using histological methods. The expression of cell type specific markers was examined by immunohistochemistry and in situ hybridization.
Results: Hectd1 is expressed in the labyrinthine zone throughout development and the protein is enriched in syncytiotrophoblast layer type I cells (SynT-I) and Sinusoidal Trophoblast Giant cells (S-TGCs) in the mature placenta. Mutation of Hectd1 results in pale placentas with frequent hemorrhages along with gross abnormalities in the structure of the labyrinthine zone including a smaller overall volume and a poorly elaborated fetal vasculature that contain fewer fetal blood cells. Examination of molecular markers of labyrinthine trophoblast cell types reveals increased Dlx3 positive cells and Syna positive SynT-I cells, along with decreased Hand1 and Ctsq positive sinusoidal trophoblast giant cells (S-TGCs).
Discussion: Together these defects indicate that Hectd1 is required for development of the labyrinthine zonethe mouse placenta.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: U54 HD090257 United States HD NICHD NIH HHS; P30 HD040677 United States HD NICHD NIH HHS; R01 HD058629 United States HD NICHD NIH HHS; P30HD040677 United States HD NICHD NIH HHS; R01-HD058629 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: HECT E3 ligase; Labyrinthine layer; Placenta
المشرفين على المادة: EC 2.3.2.26 (Hectd1 protein, mouse)
EC 2.3.2.27 (Ubiquitin-Protein Ligases)
تواريخ الأحداث: Date Created: 20160225 Date Completed: 20161213 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC4768308
DOI: 10.1016/j.placenta.2015.12.002
PMID: 26907377
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-3102
DOI:10.1016/j.placenta.2015.12.002