دورية أكاديمية
أعرض في EDS

A Distributed Network for Social Cognition Enriched for Oxytocin Receptors.

التفاصيل البيبلوغرافية
العنوان: A Distributed Network for Social Cognition Enriched for Oxytocin Receptors.
المؤلفون: Mitre M; Skirball Institute for Biomolecular Medicine, Neuroscience Institute, Department of Otolaryngology, Department of Neuroscience and Physiology., Marlin BJ; Skirball Institute for Biomolecular Medicine, Neuroscience Institute, Department of Otolaryngology, Department of Neuroscience and Physiology., Schiavo JK; Skirball Institute for Biomolecular Medicine, Neuroscience Institute, Department of Otolaryngology, Department of Neuroscience and Physiology., Morina E; Skirball Institute for Biomolecular Medicine, Neuroscience Institute, Department of Otolaryngology, Department of Neuroscience and Physiology., Norden SE; Skirball Institute for Biomolecular Medicine, Department of Cell Biology, and Department of Psychiatry, New York University School of Medicine, New York, New York 10016., Hackett TA; Vanderbilt Kennedy Center for Research on Human Development, Department of Hearing and Speech Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and., Aoki CJ; Center for Neural Science, New York University, New York, New York 10003., Chao MV; Skirball Institute for Biomolecular Medicine, Neuroscience Institute, Department of Neuroscience and Physiology, Department of Cell Biology, and Department of Psychiatry, New York University School of Medicine, New York, New York 10016, Center for Neural Science, New York University, New York, New York 10003 moses.chao@med.nyu.edu robert.froemke@med.nyu.edu., Froemke RC; Skirball Institute for Biomolecular Medicine, Neuroscience Institute, Department of Otolaryngology, Department of Neuroscience and Physiology, Center for Neural Science, New York University, New York, New York 10003 moses.chao@med.nyu.edu robert.froemke@med.nyu.edu.
المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2016 Feb 24; Vol. 36 (8), pp. 2517-35.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington, DC : Society for Neuroscience
Original Publication: [Baltimore, Md.] : The Society, c1981-
مواضيع طبية MeSH: Social Behavior*, Auditory Cortex/*metabolism , Cognition/*physiology , Nerve Net/*metabolism , Receptors, Oxytocin/*biosynthesis, Amino Acid Sequence ; Animals ; Auditory Cortex/chemistry ; Female ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Sequence Data ; Nerve Net/chemistry ; Receptors, Oxytocin/analysis ; Receptors, Oxytocin/genetics
مستخلص: Oxytocin is a neuropeptide important for social behaviors such as maternal care and parent-infant bonding. It is believed that oxytocin receptor signaling in the brain is critical for these behaviors, but it is unknown precisely when and where oxytocin receptors are expressed or which neural circuits are directly sensitive to oxytocin. To overcome this challenge, we generated specific antibodies to the mouse oxytocin receptor and examined receptor expression throughout the brain. We identified a distributed network of female mouse brain regions for maternal behaviors that are especially enriched for oxytocin receptors, including the piriform cortex, the left auditory cortex, and CA2 of the hippocampus. Electron microscopic analysis of the cerebral cortex revealed that oxytocin receptors were mainly expressed at synapses, as well as on axons and glial processes. Functionally, oxytocin transiently reduced synaptic inhibition in multiple brain regions and enabled long-term synaptic plasticity in the auditory cortex. Thus modulation of inhibition may be a general mechanism by which oxytocin can act throughout the brain to regulate parental behaviors and social cognition.
(Copyright © 2016 the authors 0270-6474/16/362517-19$15.00/0.)
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معلومات مُعتمدة: T32 NS086750 United States NS NINDS NIH HHS; NS21072 United States NS NINDS NIH HHS; DC012527 United States DC NIDCD NIH HHS; P30 HD015052 United States HD NICHD NIH HHS; U54 HD083211 United States HD NICHD NIH HHS; P30 EY013079 United States EY NEI NIH HHS; R01 DC009836 United States DC NIDCD NIH HHS; EY13079 United States EY NEI NIH HHS; DC009836 United States DC NIDCD NIH HHS; P30-HD015052-33 United States HD NICHD NIH HHS; R21MH105846 United States MH NIMH NIH HHS; DC009635 United States DC NIDCD NIH HHS; T32 MH019524 United States MH NIMH NIH HHS; K99 DC009635 United States DC NIDCD NIH HHS; R00 DC009635 United States DC NIDCD NIH HHS; R01 DC015388 United States DC NIDCD NIH HHS; R01 NS021072 United States NS NINDS NIH HHS; R01 DC012557 United States DC NIDCD NIH HHS; K18 DC012527 United States DC NIDCD NIH HHS; R56 NS021072 United States NS NINDS NIH HHS; R21 MH105846 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: antibody; auditory cortex; development; inhibition; oxytocin; synaptic plasticity
المشرفين على المادة: 0 (OXTR protein, mouse)
0 (Receptors, Oxytocin)
تواريخ الأحداث: Date Created: 20160226 Date Completed: 20160630 Latest Revision: 20230915
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4764667
DOI: 10.1523/JNEUROSCI.2409-15.2016
PMID: 26911697
قاعدة البيانات: MEDLINE
الوصف
تدمد:1529-2401
DOI:10.1523/JNEUROSCI.2409-15.2016