دورية أكاديمية
Histologic evaluation of Ki-67 and cleaved caspase-3 expression in feline mammary carcinoma.
| العنوان: | Histologic evaluation of Ki-67 and cleaved caspase-3 expression in feline mammary carcinoma. |
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| المؤلفون: | Silva MN; 1 Postgraduate Program in Pathology, Fluminense Federal University, Niterói, RJ, Brazil., Leite JS; 2 Department of Pathology and Veterinary Clinics, Faculty of Veterinary Medicine, Fluminense Federal University Niteroi, RJ, Brazil., Mello MF; 2 Department of Pathology and Veterinary Clinics, Faculty of Veterinary Medicine, Fluminense Federal University Niteroi, RJ, Brazil., Silva KV; 3 Postgraduate Program in Clinical and Animal Reproduction, Faculty of Veterinary Medicine, Fluminense Federal University, Niteroi, RJ, Brazil., Corgozinho KB; 3 Postgraduate Program in Clinical and Animal Reproduction, Faculty of Veterinary Medicine, Fluminense Federal University, Niteroi, RJ, Brazil., de Souza HJ; 4 Department of Clinical and Surgery, Veterinary Institute, Federal Rural University of Rio de Janeiro, RJ, Brazil., Cunha SC; 3 Postgraduate Program in Clinical and Animal Reproduction, Faculty of Veterinary Medicine, Fluminense Federal University, Niteroi, RJ, Brazil., Ferreira AM; 2 Department of Pathology and Veterinary Clinics, Faculty of Veterinary Medicine, Fluminense Federal University Niteroi, RJ, Brazil.; 3 Postgraduate Program in Clinical and Animal Reproduction, Faculty of Veterinary Medicine, Fluminense Federal University, Niteroi, RJ, Brazil. |
| المصدر: | Journal of feline medicine and surgery [J Feline Med Surg] 2017 Apr; Vol. 19 (4), pp. 440-445. Date of Electronic Publication: 2016 Jul 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: England NLM ID: 100897329 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2750 (Electronic) Linking ISSN: 1098612X NLM ISO Abbreviation: J Feline Med Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2012- : London : Sage Original Publication: London ; Philadelphia : WB Saunders Co., |
| مواضيع طبية MeSH: | Gene Expression Regulation, Neoplastic*, Caspase 3/*analysis , Cat Diseases/*pathology , Ki-67 Antigen/*analysis , Mammary Neoplasms, Animal/*pathology, Animals ; Caspase 3/immunology ; Cat Diseases/genetics ; Cat Diseases/immunology ; Cats ; Female ; Immunohistochemistry/veterinary ; Ki-67 Antigen/immunology ; Mammary Neoplasms, Animal/genetics ; Mammary Neoplasms, Animal/immunology |
| مستخلص: | Objectives The purpose of this study was to evaluate histopathologic aspects of, and the expression of Ki-67 and cleaved caspase-3 in, feline mammary carcinoma (FMC). Methods Feline mammary tumors were surgically obtained by mastectomy from 30 female cats and were fixed with formalin and embedded in paraffin wax. Four-micron sections were stained with hematoxylin and eosin for histopathologic diagnosis. Ki-67 and cleaved caspase-3 were analyzed by immunohistochemistry. Results Samples were histologically confirmed as FMC. Positive immunostaining was observed in all cancer samples for both nuclear Ki-67 and cleaved caspase-3, with a mean positive staining percentage of 27.5% and 21.2%, respectively. No statistically significant correlations between Ki-67 and cleaved caspase-3 were observed within FMC. Conclusions and relevance A high proliferation index was found in feline mammary tumors. This is the first study evaluating cleaved caspase-3 expression in FMC. |
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| المشرفين على المادة: | 0 (Ki-67 Antigen) EC 3.4.22.- (Caspase 3) |
| تواريخ الأحداث: | Date Created: 20160227 Date Completed: 20170825 Latest Revision: 20240626 |
| رمز التحديث: | 20240626 |
| مُعرف محوري في PubMed: | PMC11119657 |
| DOI: | 10.1177/1098612X16634150 |
| PMID: | 26917536 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-2750 |
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| DOI: | 10.1177/1098612X16634150 |