دورية أكاديمية
أعرض في EDS

Host Mitochondrial Association Evolved in the Human Parasite Toxoplasma gondii via Neofunctionalization of a Gene Duplicate.

التفاصيل البيبلوغرافية
العنوان: Host Mitochondrial Association Evolved in the Human Parasite Toxoplasma gondii via Neofunctionalization of a Gene Duplicate.
المؤلفون: Adomako-Ankomah Y; Department of Biological Sciences, Kenneth P. Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260., English ED; Department of Biological Sciences, Kenneth P. Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260., Danielson JJ; Department of Biological Sciences, Kenneth P. Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260., Pernas LF; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305., Parker ML; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, VP8 5C2, Canada., Boulanger MJ; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, VP8 5C2, Canada., Dubey JP; Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, Maryland 20705., Boyle JP; Department of Biological Sciences, Kenneth P. Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 boylej@pitt.edu.
المصدر: Genetics [Genetics] 2016 May; Vol. 203 (1), pp. 283-98. Date of Electronic Publication: 2016 Feb 26.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [Oxford] : Oxford University Press
Original Publication: Austin, Tex. [etc.]
مواضيع طبية MeSH: Gene Duplication*, Host-Parasite Interactions/*genetics , Protozoan Proteins/*genetics , Toxoplasma/*genetics , Toxoplasmosis/*parasitology, Animals ; Cats ; Gene Dosage ; Gene Expression Regulation ; Mice ; Mice, Knockout ; Multigene Family ; Transcription, Genetic
مستخلص: In Toxoplasma gondii, an intracellular parasite of humans and other animals, host mitochondrial association (HMA) is driven by a gene family that encodes multiple mitochondrial association factor 1 (MAF1) proteins. However, the importance of MAF1 gene duplication in the evolution of HMA is not understood, nor is the impact of HMA on parasite biology. Here we used within- and between-species comparative analysis to determine that the MAF1 locus is duplicated in T. gondii and its nearest extant relative Hammondia hammondi, but not another close relative, Neospora caninum Using cross-species complementation, we determined that the MAF1 locus harbors multiple distinct paralogs that differ in their ability to mediate HMA, and that only T. gondii and H. hammondi harbor HMA(+) paralogs. Additionally, we found that exogenous expression of an HMA(+) paralog in T. gondii strains that do not normally exhibit HMA provides a competitive advantage over their wild-type counterparts during a mouse infection. These data indicate that HMA likely evolved by neofunctionalization of a duplicate MAF1 copy in the common ancestor of T. gondii and H. hammondi, and that the neofunctionalized gene duplicate is selectively advantageous.
(Copyright © 2016 by the Genetics Society of America.)
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معلومات مُعتمدة: R01 AI073756 United States AI NIAID NIH HHS; R01 AI114655 United States AI NIAID NIH HHS; R01 AI116855 United States AI NIAID NIH HHS; R21 AI110351 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Hammondia hammondi*; Neospora caninum*; Toxoplasma gondii*; gene duplication*; neofunctionalization*
المشرفين على المادة: 0 (Protozoan Proteins)
تواريخ الأحداث: Date Created: 20160228 Date Completed: 20170223 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4858780
DOI: 10.1534/genetics.115.186270
PMID: 26920761
قاعدة البيانات: MEDLINE
الوصف
تدمد:1943-2631
DOI:10.1534/genetics.115.186270