دورية أكاديمية
Relationship between Adherence to Oral Antibiotics and Postdischarge Clinical Outcomes among Patients Hospitalized with Staphylococcus aureus Skin Infections.
| العنوان: | Relationship between Adherence to Oral Antibiotics and Postdischarge Clinical Outcomes among Patients Hospitalized with Staphylococcus aureus Skin Infections. |
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| المؤلفون: | Eells SJ; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Los Angeles, California, USA Science 37, Inc., and Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA., Nguyen M; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA College of Pharmacy, Western University of Health Sciences, Pomona, California, USA., Jung J; College of Pharmacy, Western University of Health Sciences, Pomona, California, USA., Macias-Gil R; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA., May L; Department of Emergency Medicine, University of California-Davis, Sacramento, California, USA., Miller LG; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Los Angeles, California, USA Lgmiller@ucla.edu. |
| المصدر: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Apr 22; Vol. 60 (5), pp. 2941-8. Date of Electronic Publication: 2016 Apr 22 (Print Publication: 2016). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*therapeutic use , Staphylococcal Infections/*drug therapy , Staphylococcal Skin Infections/*drug therapy , Staphylococcus aureus/*drug effects , Staphylococcus aureus/*pathogenicity, Administration, Oral ; Anti-Bacterial Agents/administration & dosage ; Humans ; Linear Models ; Multivariate Analysis ; Prospective Studies ; Risk Factors ; Staphylococcal Infections/microbiology ; Staphylococcal Skin Infections/microbiology |
| مستخلص: | Skin and soft tissue infections are common and frequently recur. Poor adherence to antibiotic therapy may lead to suboptimal clinical outcomes. However, adherence to oral antibiotic therapy for skin and soft tissue infections and its relationship to clinical outcomes have not been examined. We enrolled adult patients hospitalized with uncomplicated skin and soft tissue infections caused by Staphylococcus aureus who were being discharged with oral antibiotics to complete therapy. We fit the participants' pill bottles with an electronic bottle cap that recorded each pill bottle opening, administered an in-person standardized questionnaire at enrollment, 14 days, and 30 days, and reviewed the participants' medical records to determine outcomes. Our primary outcome was poor clinical response, defined as a change in antibiotic therapy, new incision-and-drainage procedure, or new skin infection within 30 days of hospital discharge. Of our 188 participants, 87 had complete data available for analysis. Among these participants, 40 (46%) had a poor clinical response at 30 days. The mean electronically measured adherence to antibiotic therapy was significantly different than the self-reported adherence (57% versus 96%; P < 0.0001). In a multivariable model, poor clinical response at 30 days was associated with patients having lower adherence, being nondiabetic, and reporting a lack of illicit drug use within the previous 12 months (P < 0.05). In conclusion, we found that patient adherence to oral antibiotic therapy for a skin and soft tissue infection after hospital discharge was low (57%) and associated with poor clinical outcome. Patients commonly overstate their medication adherence, which may make identification of patients at risk for nonadherence and poor outcomes challenging. Further studies are needed to improve postdischarge antibiotic adherence after skin and soft tissue infections. (Copyright © 2016, American Society for Microbiology. All Rights Reserved.) |
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| المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20160302 Date Completed: 20170915 Latest Revision: 20220321 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4862485 |
| DOI: | 10.1128/AAC.02626-15 |
| PMID: | 26926634 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-6596 |
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| DOI: | 10.1128/AAC.02626-15 |