دورية أكاديمية
Epidemiological Outbreaks of Pneumocystis jirovecii Pneumonia Are Not Limited to Kidney Transplant Recipients: Genotyping Confirms Common Source of Transmission in a Liver Transplantation Unit.
| العنوان: | Epidemiological Outbreaks of Pneumocystis jirovecii Pneumonia Are Not Limited to Kidney Transplant Recipients: Genotyping Confirms Common Source of Transmission in a Liver Transplantation Unit. |
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| المؤلفون: | Desoubeaux G; CHU de Tours, Service de Parasitologie-Mycologie-Médecine Tropicale, Tours, France Université François-Rabelais, CEPR, INSERM U1100/Équipe 3, Faculté de Médecine, Tours, France guillaume.desoubeaux@univ-tours.fr., Dominique M; CHU de Tours, Service de Parasitologie-Mycologie-Médecine Tropicale, Tours, France., Morio F; CHU de Nantes, Institut de Biologie, Laboratoire de Parasitologie-Mycologie, Nantes, France Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Faculté de Pharmacie, Nantes, France., Thepault RA; Université François-Rabelais, Imagerie et Cerveau, INSERM U930/Équipe 2, Faculté de Médecine, Tours, France., Franck-Martel C; CHU de Tours, Service de Parasitologie-Mycologie-Médecine Tropicale, Tours, France., Tellier AC; CHU de Tours, Service de Réanimation Chirurgicale, Tours, France., Ferrandière M; CHU de Tours, Service de Réanimation Chirurgicale, Tours, France., Hennequin C; CHU Saint-Antoine, Laboratoire de Parasitologie & Mycologie, Paris, France Université Pierre et Marie Curie-Paris 6, INSERM UMR-S 945, Paris, France., Bernard L; Université François-Rabelais, CEPR, INSERM U1100/Équipe 3, Faculté de Médecine, Tours, France CHU de Tours, Service de Médecine Interne & Maladies Infectieuses, Tours, France., Salamé E; CHU de Tours, Service de Chirurgie Digestive, Endocrinienne et Transplantation Hépatique, Tours, France., Bailly É; CHU de Tours, Service de Parasitologie-Mycologie-Médecine Tropicale, Tours, France., Chandenier J; CHU de Tours, Service de Parasitologie-Mycologie-Médecine Tropicale, Tours, France Université François-Rabelais, CEPR, INSERM U1100/Équipe 3, Faculté de Médecine, Tours, France. |
| المصدر: | Journal of clinical microbiology [J Clin Microbiol] 2016 May; Vol. 54 (5), pp. 1314-20. Date of Electronic Publication: 2016 Mar 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7505564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-660X (Electronic) Linking ISSN: 00951137 NLM ISO Abbreviation: J Clin Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology. |
| مواضيع طبية MeSH: | Disease Outbreaks* , Transplant Recipients*, Kidney Transplantation/*adverse effects , Pneumocystis carinii/*isolation & purification , Pneumonia, Pneumocystis/*epidemiology, Aged ; Bronchoalveolar Lavage Fluid/microbiology ; Female ; Humans ; Male ; Middle Aged ; Molecular Epidemiology ; Multilocus Sequence Typing ; Mycological Typing Techniques ; Pneumocystis carinii/classification ; Pneumocystis carinii/genetics |
| مستخلص: | Over a 5-month period, four liver transplant patients at a single hospital were diagnosed with Pneumocystis jirovecii pneumonia (PCP). This unusually high incidence was investigated using molecular genotyping. Bronchoalveolar lavage fluids (BALF) obtained from the four liver recipients diagnosed with PCP were processed for multilocus sequence typing (MLST) at three loci (SOD, mt26s, and CYB). Twenty-four other BALF samples, which were positive for P. jirovecii and collected from 24 epidemiologically unrelated patients with clinical signs of PCP, were studied in parallel by use of the same method. Pneumocystis jirovecii isolates from the four liver recipients all had the same genotype, which was different from those of the isolates from all the epidemiologically unrelated individuals studied. These findings supported the hypothesis of a common source of contamination or even cross-transmission of a single P. jirovecii clone between the four liver recipients. Hospitalization mapping showed several possible encounters between these four patients, including outpatient consultations on one particular date when they all possibly met. This study demonstrates the value of molecular genotyping of P. jirovecii isolated from clinical samples for epidemiological investigation of PCP outbreaks. It is also the first description of a common source of exposure to a single P. jirovecii clone between liver transplant recipients and highlights the importance of prophylaxis in such a population. (Copyright © 2016, American Society for Microbiology. All Rights Reserved.) |
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| تواريخ الأحداث: | Date Created: 20160304 Date Completed: 20170714 Latest Revision: 20181113 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC4844736 |
| DOI: | 10.1128/JCM.00133-16 |
| PMID: | 26935726 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-660X |
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| DOI: | 10.1128/JCM.00133-16 |