دورية أكاديمية
أعرض في EDS

Attachment issues: kinetochore transformations and spindle checkpoint silencing.

التفاصيل البيبلوغرافية
العنوان: Attachment issues: kinetochore transformations and spindle checkpoint silencing.
المؤلفون: Etemad B; Hubrecht Institute - KNAW (Royal Netherlands Academy of Arts and Sciences), Uppsalalaan 8, 3584 CT Utrecht, The Netherlands., Kops GJ; Hubrecht Institute - KNAW (Royal Netherlands Academy of Arts and Sciences), Uppsalalaan 8, 3584 CT Utrecht, The Netherlands; Cancer Genomics Netherlands, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands; Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands. Electronic address: g.kops@hubrecht.eu.
المصدر: Current opinion in cell biology [Curr Opin Cell Biol] 2016 Apr; Vol. 39, pp. 101-8. Date of Electronic Publication: 2016 Mar 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 8913428 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0410 (Electronic) Linking ISSN: 09550674 NLM ISO Abbreviation: Curr Opin Cell Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Elsevier
Original Publication: Philadelphia, PA, USA : Current Science, c1988-
مواضيع طبية MeSH: Kinetochores*/metabolism , Spindle Apparatus*/metabolism, Anaphase ; Animals ; Cell Cycle Checkpoints ; Humans ; Microtubules/metabolism ; Signal Transduction
مستخلص: Cell division culminates in the segregation of duplicated chromosomes in opposite directions prior to cellular fission. This process is guarded by the spindle assembly checkpoint (SAC), which prevents the anaphase of cell division until stable connections between spindle microtubules and the kinetochores of all chromosomes are established. The anaphase inhibitor is generated at unattached kinetochores and inhibitor production is prevented when microtubules are captured. Understanding the molecular changes in the kinetochore that are evoked by microtubule attachments is crucial for understanding the mechanisms of SAC signaling and silencing. Here, we highlight the most recent findings on these events, pinpoint some remaining mysteries, and argue for incorporating holistic views of kinetochore dynamics in order to understand SAC silencing.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
تواريخ الأحداث: Date Created: 20160308 Date Completed: 20161013 Latest Revision: 20181202
رمز التحديث: 20240628
DOI: 10.1016/j.ceb.2016.02.016
PMID: 26947988
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0410
DOI:10.1016/j.ceb.2016.02.016