دورية أكاديمية
أعرض في EDS

Causal Model of Survival After Pulmonary Metastasectomy of Colorectal Cancer: A Nationwide Prospective Registry.

التفاصيل البيبلوغرافية
العنوان: Causal Model of Survival After Pulmonary Metastasectomy of Colorectal Cancer: A Nationwide Prospective Registry.
المؤلفون: Embun R; Department of Thoracic Surgery, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain. Electronic address: raulembun@gmail.com., Rivas de Andrés JJ; Department of Thoracic Surgery, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain., Call S; Department of Thoracic Surgery, Hospital Universitari Mutua Terrasa, Terrasa, Barcelona, Spain., de Olaiz Navarro B; Department of Thoracic Surgery, Hospital Universitario de Getafe, Getafe, Madrid, Spain., Freixinet JL; Department of Thoracic Surgery, Hospital Universitario de Gran Canaria Doctor Negrín, Gran Canaria, Islas Canarias, Spain., Bolufer S; Department of Thoracic Surgery, Hospital General Universitario de Alicante, Alicante, Spain., Jarabo JR; Department of Thoracic Surgery, Hospital Clínico San Carlos, Madrid, Spain., Pajuelo N; Department of Biostatistics and Data Management, Dynamic Solutions, Madrid, Spain., Molins L; Department of Thoracic Surgery, Hospital Universitari Sagrat Cor, Barcelona, Spain.
مؤلفون مشاركون: Spanish Group of Lung Metastases of Colo-Rectal Cancer (GECMP-CCR) of the Spanish Society of Pneumology and Thoracic Surgery (SEPAR)
المصدر: The Annals of thoracic surgery [Ann Thorac Surg] 2016 May; Vol. 101 (5), pp. 1883-90. Date of Electronic Publication: 2016 Mar 05.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 15030100R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-6259 (Electronic) Linking ISSN: 00034975 NLM ISO Abbreviation: Ann Thorac Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Boston.
مواضيع طبية MeSH: Colorectal Neoplasms/*pathology , Lung Neoplasms/*secondary , Metastasectomy/*mortality, Carcinoembryonic Antigen/blood ; Cohort Studies ; Colorectal Neoplasms/mortality ; Female ; Humans ; Lung Neoplasms/mortality ; Lung Neoplasms/surgery ; Lymph Nodes/pathology ; Male ; Prospective Studies ; Registries
مستخلص: Background: Although numerous existing studies have analyzed the prognostic factors of patients who have had surgical intervention for lung metastases of colorectal carcinoma (CRC), many of the results obtained until now have been contradictory. As a consequence, there is no established consensus about which group of prognostic factors could have a greater value when considered together.
Methods: This was a multicenter prospective cohort study that included all patients who underwent a first pulmonary metastasectomy of CRC, with radical intent, during a 2-year period (March 2008 to February 2010). The follow-up continued until March 2013, and an analysis of disease-specific survival (DSS), determined from the first pulmonary metastasectomy, was implemented. The selection of the best submodel was taken based on their coefficient of determination (R(2)) and how parsimonious they were depending on the number of variables included.
Results: The series, consisting of 522 patients, presented the following survival rates: median, 54.9 months; 3-year DSS, 69.4% (95% confidence interval [CI], 65% to 73.8%); and 5-year DSS, 46.1% (95% CI, 38.5% to 53.7%). The resulting survival model consisted of disease-free interval of 12 months or less (hazard ratio [HR], 1.76; 95% CI, 1.21 to 2.54; p = 0.003), carcinoembryonic antigen level exceeding 5 ng/mL (HR, 1.50; 95% CI, 1.04 to 2.17; p = 0.028), bilateral lung disease (HR, 1.81; 95% CI, 1.20 to 2.75; p = 0.005), and thoracic lymph node involvement (HR, 2.71; 95% CI, 1.44 to 5.12; p = 0.002).
Conclusions: According to these results from the Spanish Group of Lung Metastases of Colo-Rectal Cancer, the combination of these four variables-disease-free interval, carcinoembryonic antigen level, laterality, and thoracic lymph node involvement-constitutes the first-choice survival causal model based on the clinical and pathologic factors most frequently referenced in literature.
(Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Investigator: JJ Rivas; L Molins; R Embun; F Rivas-Doyague; R Embun; J Hernández-Ferrández; F Heras; J de la Cruz; M Rubio; E Fernández; M Carbajo; R Peñalver; JR Jarabo; D González-Rivas; S Bolufer; C Pagés; S Call; D Smith; R Wins; A Arnau; A Arroyo; C Marrón; A Tamura; M Blanco; B de Olaiz; G Muñoz; JM García Prim; C Rombolá; S García-Barajas; A Rodríguez-Fuster; JL Freixinet; J Ruiz-Zafra; G Carriquiry; M Rosenberg; E Canalís
المشرفين على المادة: 0 (Carcinoembryonic Antigen)
تواريخ الأحداث: Date Created: 20160309 Date Completed: 20170227 Latest Revision: 20220318
رمز التحديث: 20240628
DOI: 10.1016/j.athoracsur.2015.12.017
PMID: 26952293
قاعدة البيانات: MEDLINE
الوصف
تدمد:1552-6259
DOI:10.1016/j.athoracsur.2015.12.017