دورية أكاديمية
[A comparative analysis of mutagenic and SOS-induced activity in three classes of chemical compounds].
| العنوان: | [A comparative analysis of mutagenic and SOS-induced activity in three classes of chemical compounds]. |
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| عنوان ترانسليتريتد: | Sravnitel'nyĭ analiz mutagennoĭ i SOS-indutsiruiushcheĭ aktivnosti u khimicheskikh soedineniĭ trekh klassov. |
| المؤلفون: | Vasil'eva SV, Tanirbergenov TB, Abilev SK, Migachev GI |
| المصدر: | Genetika [Genetika] 1989 Oct; Vol. 25 (10), pp. 1740-6. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0047354 Publication Model: Print Cited Medium: Print ISSN: 0016-6758 (Print) Linking ISSN: 00166758 NLM ISO Abbreviation: Genetika Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: | DNA Repair* , Mutagenicity Tests* , Mutagens* , SOS Response, Genetics*, Biphenyl Compounds/*toxicity , Fluorenes/*toxicity , Phenanthrenes/*toxicity, Escherichia coli/genetics ; Genes, Bacterial ; Mutation ; Salmonella typhimurium/genetics |
| مستخلص: | Mutagenic and SOS-inducing potential of 23 derivatives of fluorenone, phenanthrenequinone and biphenyl have been studied in tester strains of Salmonella typhimurium and in Escherichia coli strain PQ 37. 14 of these compounds revert the mutation hisD3052 (much less than -1 much greater than type), but none of them induce mutations in the strain TA 1535. Maximal mutagenic activity has been shown in strain TA 1538 for amide of 2,7-dinitrofluorenone-4-carbonic acid (580 revertants per nmol), 2,7-dinitrophenanthrenequinone (308 revertants per nmol), 2,4,7-trinitrophenanthrenequinone (306 revertants per nmol) and 2',4,4'-trinitrobiphenyl-2-carbonic acid (251 revertants per nmol). In plasmid-containing strain TA 98 the mutagenic potential of the compounds tested is lower than in the TA 1538 strain. It has been suggested that mutagenic activity of these compounds can be attributed to their acceptor properties, namely, the ability to form charge transfer complexes with DNA. SOS-inducing activity has been shown for 5 compounds, also positive in mutation induction. Mutagenic and SOS-inducing activities positively correlate in fluorenone derivatives. Among phenanthrenequinone derivatives, compounds with high mutagenic activity only can induce SOS response. None of the biphenyls tested induce SOS functions. The compounds giving the positive result in the SOS-chromotest have rigid co-planar structure. |
| المشرفين على المادة: | 0 (Biphenyl Compounds) 0 (Fluorenes) 0 (Mutagens) 0 (Phenanthrenes) 42L7BZ8H74 (9,10-phenanthrenequinone) |
| تواريخ الأحداث: | Date Created: 19891001 Date Completed: 19900329 Latest Revision: 20191210 |
| رمز التحديث: | 20221208 |
| PMID: | 2695388 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0016-6758 |
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