دورية أكاديمية
أعرض في EDS

The use of 18 F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer.

التفاصيل البيبلوغرافية
العنوان: The use of 18 F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer.
المؤلفون: Rashidian M; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142., Keliher E; Center for Systems Biology Department, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114 (USA)., Dougan M; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Department of Gastroenterology, Massachusetts General Hospital Boston, 185 Cambridge St., MA 02114., Juras PK; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Cavallari M; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Wojtkiewicz GR; Center for Systems Biology Department, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114 (USA)., Jacobsen J; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Edens JG; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Tas JM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Victora G; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Weissleder R; Center for Systems Biology Department, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114 (USA); Department of Systems Biology, Harvard Medical School 200 Longwood Ave, Boston, MA 02115., Ploegh H; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.
المصدر: ACS central science [ACS Cent Sci] 2015 Jun 24; Vol. 1 (3), pp. 142-147. Date of Electronic Publication: 2015 Jun 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101660035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2374-7943 (Print) Linking ISSN: 23747943 NLM ISO Abbreviation: ACS Cent Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Washington DC : ACS Publications, [2015]-
مستخلص: We generated 18 F-labeled antibody fragments for PET imaging using a sortase-mediated reaction to install a transcyclooctene (TCO)-functionalized short peptide onto proteins of interest, followed by reaction with a tetrazine-labeled- 18 F-2-deoxyfluoroglucose (FDG). The method is rapid, robust, and site-specific (radiochemical yields >25%, not decay corrected). The availability of 18 F-2-deoxyfluoroglucose avoids the need for more complicated chemistries used to generate carbon-fluorine bonds. We demonstrate the utility of the method by detecting heterotopic pancreatic tumors in mice by PET, using anti-Class II MHC single domain antibodies. We correlate macroscopic PET images with microscopic two-photon visualization of the tumor. Our approach provides easy access to 18 F-labeled antibodies and their fragments at a level of molecular specificity that complements conventional 18 F-FDG imaging.
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معلومات مُعتمدة: DP1 GM106409 United States GM NIGMS NIH HHS; P50 CA086355 United States CA NCI NIH HHS; P01 CA117969 United States CA NCI NIH HHS; R01 EB010011 United States EB NIBIB NIH HHS; R21 AI117373 United States AI NIAID NIH HHS; R01 AI087879 United States AI NIAID NIH HHS; R01 GM100518 United States GM NIGMS NIH HHS
تواريخ الأحداث: Date Created: 20160309 Latest Revision: 20200929
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4778250
DOI: 10.1021/acscentsci.5b00121
PMID: 26955657
قاعدة البيانات: MEDLINE
الوصف
تدمد:2374-7943
DOI:10.1021/acscentsci.5b00121