دورية أكاديمية
A liposomal steroid nano-drug for treating systemic lupus erythematosus.
| العنوان: | A liposomal steroid nano-drug for treating systemic lupus erythematosus. |
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| المؤلفون: | Moallem E; Department of Medicine-Hadassah University Hospital, Jerusalem, Israel., Koren E; The Laboratory of Membrane and Liposome Research, Department of Biochemistry, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel., Ulmansky R; Department of Medicine-Hadassah University Hospital, Jerusalem, Israel., Pizov G; Department of Medicine-Hadassah University Hospital, Jerusalem, Israel., Barlev M; The Laboratory of Membrane and Liposome Research, Department of Biochemistry, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel., Barenholz Y; The Laboratory of Membrane and Liposome Research, Department of Biochemistry, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel., Naparstek Y; Department of Medicine-Hadassah University Hospital, Jerusalem, Israel yakovn@hadassah.org.il chezyb1@gmail.com. |
| المصدر: | Lupus [Lupus] 2016 Oct; Vol. 25 (11), pp. 1209-16. Date of Electronic Publication: 2016 Mar 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : SAGE Publications Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991- |
| مواضيع طبية MeSH: | Lupus Erythematosus, Systemic/*drug therapy , Methylprednisolone Hemisuccinate/*administration & dosage , Nanoparticles/*administration & dosage, Animals ; Antibodies, Antinuclear/metabolism ; Disease Models, Animal ; Drug Administration Schedule ; Female ; Liposomes/administration & dosage ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/metabolism ; Mice ; Mice, Inbred MRL lpr ; Treatment Outcome |
| مستخلص: | Background: Glucocorticoids have been known for years to be the most effective therapy in systemic lupus erythematosus. Their use, however, is limited by the need for high doses due to their unfavorable pharmacokinetics and biodistribution. We have previously developed a novel liposome-based steroidal (methylprednisolone hemisuccinate (MPS)) nano-drug and demonstrated its specific accumulation in inflamed tissues, as well as its superior therapeutic efficacy over that of free glucocorticoids (non-liposomal) in the autoimmune diseases, including the adjuvant arthritis rat model and the experimental autoimmune encephalomyelitis mouse model. Objectives: In the present work we have evaluated the therapeutic effect of the above liposome-based steroidal (MPS) nano-drug in the MRL-lpr/lpr murine model of SLE and compared it with similar doses of the free MPS. Methods: MRL-lpr/lpr mice were treated with daily injections of free MPS or weekly injections of 10% dextrose, empty nano-liposomes or the steroidal nano-drug and the course of their disease was followed up to the age of 24 weeks. Results: Treatment with the steroidal nano-drug was found to be significantly superior to the free MPS in suppressing anti-dsDNA antibody levels, proliferation of lymphoid tissue and renal damage, and in prolonging survival of animals. Conclusion: This significant superiority of our liposome based steroidal nano-drug administered weekly compared with daily injections of free methylprednisolone hemisuccinate in suppressing murine lupus indicates this glucocorticoid nano-drug formulation may be a good candidate for the treatment of human SLE. (© The Author(s) 2016.) |
| فهرسة مساهمة: | Keywords: Systemic lupus erythematosus; corticosteroids; treatment |
| المشرفين على المادة: | 0 (Antibodies, Antinuclear) 0 (Liposomes) 5GMR90S4KN (Methylprednisolone Hemisuccinate) |
| تواريخ الأحداث: | Date Created: 20160310 Date Completed: 20170411 Latest Revision: 20170411 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/0961203316636468 |
| PMID: | 26957351 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1477-0962 |
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| DOI: | 10.1177/0961203316636468 |