دورية أكاديمية
أعرض في EDS

Effect of forced treadmill exercise and blocking of opioid receptors with naloxone on memory in male rats.

التفاصيل البيبلوغرافية
العنوان: Effect of forced treadmill exercise and blocking of opioid receptors with naloxone on memory in male rats.
المؤلفون: Rizi AA; Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran., Reisi P; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Naghsh N; Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
المصدر: Advanced biomedical research [Adv Biomed Res] 2016 Feb 08; Vol. 5, pp. 20. Date of Electronic Publication: 2016 Feb 08 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Publications and Media Pvt. Ltd Country of Publication: India NLM ID: 101586897 Publication Model: eCollection Cited Medium: Print ISSN: 2277-9175 (Print) Linking ISSN: 22779175 NLM ISO Abbreviation: Adv Biomed Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Mumbai, India : Medknow Publications and Media Pvt. Ltd.
مستخلص: Background: The forced treadmill running can influence the opioid contents of the brain, through both effects of exercise and the effects of stress caused by coercion. Since opioids can cause negative effects on brain functions, this study aimed to evaluate the effect of forced treadmill exercise and blocking of opioid receptors with naloxone on memory in male rats.
Materials and Methods: Experimental groups were the control, the exercise, the naloxone, and the naloxone exercise. The exercise program was treadmill running at 22 m/min at 0° inclination for 50 min/day, 6 days/week, for 4 weeks. Naloxone (1 mg/kg) was injected 5 min before the treadmill running. Morris water maze and passive avoidance learning tests were used for evaluation of memory. Acquisition phase of both tests was performed before interventions, and memory was evaluated 1-day and 1-week after the last session of exercise and treatments.
Results: Our data showed that forced exercise impaired performance in passive avoidance learning test (P < 0.05 and P <0.01, 1-day, and 1-week after the last session of exercise and treatments, respectively). Spatial memory was only impaired after 1-week in the exercise group. Naloxone had no significant effect on memory in the control group. However, it improved memory in the exercise group, as there was no significant difference between the control and the naloxone exercise in both tests.
Conclusion: The data correspond to the possibility that opioidergic system may have mediatory roles in exercise-induced responses in forced exercise. These roles are likely harmful for memory.
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فهرسة مساهمة: Keywords: Forced treadmill running; memory; naloxone; rat
تواريخ الأحداث: Date Created: 20160311 Date Completed: 20160310 Latest Revision: 20220330
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4770631
DOI: 10.4103/2277-9175.175906
PMID: 26962522
قاعدة البيانات: MEDLINE
الوصف
تدمد:2277-9175
DOI:10.4103/2277-9175.175906