دورية أكاديمية
أعرض في EDS

Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila.

التفاصيل البيبلوغرافية
العنوان: Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila.
المؤلفون: Levine MT; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA., Vander Wende HM; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA., Hsieh E; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA., Baker EP; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA., Malik HS; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, hsmalik@fhcrc.org.
المصدر: Molecular biology and evolution [Mol Biol Evol] 2016 Jul; Vol. 33 (7), pp. 1641-53. Date of Electronic Publication: 2016 Mar 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 8501455 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-1719 (Electronic) Linking ISSN: 07374038 NLM ISO Abbreviation: Mol Biol Evol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : New York, NY : Oxford University Press
Original Publication: [Chicago, Ill.] : University of Chicago Press, [c1983-
مواضيع طبية MeSH: Gene Duplication*, Chromosomal Proteins, Non-Histone/*genetics , Drosophila Proteins/*genetics , Drosophila melanogaster/*genetics, Animals ; DNA Transposable Elements/genetics ; Evolution, Molecular ; Female ; Gene Silencing ; Genetic Variation ; Genome, Insect ; Genomic Instability ; RNA, Small Interfering/genetics ; Selection, Genetic
مستخلص: Transposable elements (TEs) comprise large fractions of many eukaryotic genomes and imperil host genome integrity. The host genome combats these challenges by encoding proteins that silence TE activity. Both the introduction of new TEs via horizontal transfer and TE sequence evolution requires constant innovation of host-encoded TE silencing machinery to keep pace with TEs. One form of host innovation is the adaptation of existing, single-copy host genes. Indeed, host suppressors of TE replication often harbor signatures of positive selection. Such signatures are especially evident in genes encoding the piwi-interacting-RNA pathway of gene silencing, for example, the female germline-restricted TE silencer, HP1D/Rhino Host genomes can also innovate via gene duplication and divergence. However, the importance of gene family expansions, contractions, and gene turnover to host genome defense has been largely unexplored. Here, we functionally characterize Oxpecker, a young, tandem duplicate gene of HP1D/rhino We demonstrate that Oxpecker supports female fertility in Drosophila melanogaster and silences several TE families that are incompletely silenced by HP1D/Rhino in the female germline. We further show that, like Oxpecker, at least ten additional, structurally diverse, HP1D/rhino-derived daughter and "granddaughter" genes emerged during a short 15-million year period of Drosophila evolution. These young paralogs are transcribed primarily in germline tissues, where the genetic conflict between host genomes and TEs plays out. Our findings suggest that gene family expansion is an underappreciated yet potent evolutionary mechanism of genome defense diversification.
(© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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معلومات مُعتمدة: R00 GM107351 United States GM NIGMS NIH HHS; K99 GM107351 United States GM NIGMS NIH HHS; P30 CA015704 United States CA NCI NIH HHS; R01 GM074108 United States GM NIGMS NIH HHS; F32 GM097897 United States GM NIGMS NIH HHS; S10 OD020069 United States OD NIH HHS; United States HHMI Howard Hughes Medical Institute
فهرسة مساهمة: Keywords: HP1 proteins; gene duplication; genome defense; heterochromatin; transposable elements
المشرفين على المادة: 0 (Chromosomal Proteins, Non-Histone)
0 (DNA Transposable Elements)
0 (Drosophila Proteins)
0 (RNA, Small Interfering)
0 (rhi protein, Drosophila)
تواريخ الأحداث: Date Created: 20160317 Date Completed: 20170712 Latest Revision: 20190607
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5010033
DOI: 10.1093/molbev/msw053
PMID: 26979388
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-1719
DOI:10.1093/molbev/msw053