دورية أكاديمية
Syntheses and Antibiotic Evaluation of 2-{[(2R,4R)-4-Carboxy-2-hydroxypyrrolidin-1-yl]carbonyl}benzene-1,5-dicarboxylic Acids and 2-Carbamoylbenzene-1,5-dicarboxylic Acid Analogues.
| العنوان: | Syntheses and Antibiotic Evaluation of 2-{[(2R,4R)-4-Carboxy-2-hydroxypyrrolidin-1-yl]carbonyl}benzene-1,5-dicarboxylic Acids and 2-Carbamoylbenzene-1,5-dicarboxylic Acid Analogues. |
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| المؤلفون: | Tukur A; Department of Chemistry, Ahmadu Bello University, Zaria 810001, Nigeria., Bello IA; Department of Chemistry, Ahmadu Bello University, Zaria 810001, Nigeria., Koorbanally NA; School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X 54001, Durban 4000, South Africa., Habila JD; Department of Chemistry, Ahmadu Bello University, Zaria 810001, Nigeria. |
| المصدر: | International journal of medicinal chemistry [Int J Med Chem] 2016; Vol. 2016, pp. 9346585. Date of Electronic Publication: 2016 Feb 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Publishing Corporation Country of Publication: United States NLM ID: 101622092 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2090-2069 (Print) Linking ISSN: 20902077 NLM ISO Abbreviation: Int J Med Chem Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Hindawi Publishing Corporation, [2011]-[2019] |
| مستخلص: | Our search for new antibiotics led to the syntheses and biological evaluation of new classes of dicarboxylic acid analogues. The syntheses involve nucleophilic addition of different substituted benzylamine, aniline, alkylamine, and 4-hydroxyl-L-proline with carbamoylbenzoic acid. The results of the antimicrobial activity as indicated by the zone of inhibition (ZOI) showed that Z 10 is the most active against Pseudomonas aeruginosa (32 mm) and least active against Candida stellatoidea (27 mm) and Vancomycin Resistant Enterococci (VRE) (27 mm), while Z 7 shows the least zone of inhibition (22 mm) against Methicillin Resistant Staphylococcus aureus (MRSA). The minimum inhibition concentration (MIC) determination reveals that Z 10 inhibits the growth of tested microbes at a low concentration of 6.25 μg/mL, while Z 9 and Z 12 inhibits the growth of most microbes at a concentration of 12.5 μg/mL, recording the least MIC. The Minimum Bactericidal/Fungicidal Concentration (MBC/MFC) results revealed that Z 10 has the highest bactericidal/fungicidal effect on the test microbes, at a concentration of 12.5 μg/mL, with the exception of Candida stellatoidea and Vancomycin Resistant Enterococci (VRE) with MBC/MFC of 25 μg/mL. The result of this investigation reveals the potential of the target compounds (Z 1-3,5,7-12 ) in the search for new antimicrobial agents. |
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| تواريخ الأحداث: | Date Created: 20160317 Date Completed: 20160316 Latest Revision: 20201001 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4769762 |
| DOI: | 10.1155/2016/9346585 |
| PMID: | 26981281 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2090-2069 |
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| DOI: | 10.1155/2016/9346585 |