دورية أكاديمية
Translational control by eIF2α in neurons: Beyond the stress response.
| العنوان: | Translational control by eIF2α in neurons: Beyond the stress response. |
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| المؤلفون: | Bellato HM; International Research Center, A.C. Camargo Cancer Center, São Paulo, 01508-010, Brazil., Hajj GN; International Research Center, A.C. Camargo Cancer Center, São Paulo, 01508-010, Brazil. ghajj@cipe.accamargo.org.br. |
| المصدر: | Cytoskeleton (Hoboken, N.J.) [Cytoskeleton (Hoboken)] 2016 Oct; Vol. 73 (10), pp. 551-565. Date of Electronic Publication: 2016 May 09. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 101523844 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-3592 (Electronic) Linking ISSN: 19493592 NLM ISO Abbreviation: Cytoskeleton (Hoboken) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, NJ : Wiley-Liss, 2010- |
| مواضيع طبية MeSH: | Memory Consolidation* , Peptide Chain Initiation, Translational*, Eukaryotic Initiation Factor-2/*metabolism , Nervous System/*metabolism , Neurodegenerative Diseases/*metabolism , Neurons/*metabolism, Animals ; Eukaryotic Initiation Factor-2/genetics ; Humans ; Nervous System/pathology ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/pathology ; Neurons/pathology ; Phosphorylation/genetics |
| مستخلص: | The translation of mRNAs is a tightly controlled process that responds to multiple signaling pathways. In neurons, this control is also exerted locally due to the differential necessity of proteins in axons and dendrites. The phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2α) is one of the mechanisms of translational control. The phosphorylation of eIF2α has classically been viewed as a stress response, halting translation initiation. However, in the nervous system this type of regulation has been related to other mechanisms besides stress response, such as behavior, memory consolidation and nervous system development. Additionally, neurodegenerative diseases have a major stress component, thus eIF2α phosphorylation plays a preeminent role and its modulation is currently viewed as a new opportunity for therapeutic interventions. This review consolidates current information regarding eIF2α phosphorylation in neurons and its impact in neurodegenerative diseases. © 2016 Wiley Periodicals, Inc. (© 2016 Wiley Periodicals, Inc.) |
| فهرسة مساهمة: | Keywords: eIF2α; mRNA translation; memory consolidation; neurodegenerative diseases; neuron |
| المشرفين على المادة: | 0 (Eukaryotic Initiation Factor-2) |
| تواريخ الأحداث: | Date Created: 20160320 Date Completed: 20171120 Latest Revision: 20171128 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/cm.21294 |
| PMID: | 26994324 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1949-3592 |
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| DOI: | 10.1002/cm.21294 |