دورية أكاديمية
Better prognosis in overweight/obese coronary heart disease patients with high plasma levels of leptin.
| العنوان: | Better prognosis in overweight/obese coronary heart disease patients with high plasma levels of leptin. |
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| المؤلفون: | Simiti LA; 1 Department of Internal Medicine, Cardiology and Gastroenterology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Todor I; Department of Cardiology, Clinical Hospital County, Cluj-Napoca, Romania., Stoia MA; 1 Department of Internal Medicine, Cardiology and Gastroenterology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Goidescu CM; 1 Department of Internal Medicine, Cardiology and Gastroenterology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Anton FP; 1 Department of Internal Medicine, Cardiology and Gastroenterology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Farcas AD; 1 Department of Internal Medicine, Cardiology and Gastroenterology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. |
| المصدر: | Clujul medical (1957) [Clujul Med] 2016; Vol. 89 (1), pp. 65-71. Date of Electronic Publication: 2016 Jan 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: |
| أسماء مطبوعة: | Publication: Cluj-Napoca : Universitatea de Medicina si Farmacie "Iuliu Hatieganu" Cluj Napoca, 1970-2018. Original Publication: Cluj : Institutul Medico-Farmaceutic |
| مستخلص: | Background and Aim: The involvement of leptin in atherosclerosis is very complex, including inflammation, the oxidative stress and thrombosis. Leptin has atherogenic and also antiatherogenic actions. In obesity elevated leptin levels are not sufficient to prevent disturbances of energy balance, suggesting that obese people are leptin resistant. The aim of the study was to investigate the relationship between baseline plasma levels of leptin and the incidence of new ischemic events in patients with CHD. Methods: Plasma levels of leptin in fifty nine consecutive patients (29 men and 30 women) with CHD hospitalized in the County Emergency Clinical Hospital of Cluj-Napoca were measured using commercially available ELISA at admission. Patients with active infectious disease, neoplasia, acute coronary syndrome, stroke, hepatic or renal failure and severe heart failure were excluded The relationship between leptin levels and incident cardiovascular events (angina, nonfatal myocardial infarction or heart failure) over two years follow-up was studied using MEDCALC version 9.6. Results: 73.6% patients with CHD were overweight or suffered of obesity. There were no significant differences between women and men regarding the plasma levels of leptin, the body mass index (BMI), the number of rehospitalizations, rehospitalizations/patient, diabetes mellitus, hypertension or dyslipidemia. Only in women plasma levels of leptin are correlated with BMI. As compared with men with overweight and obesity (BMI≥25kg/m(2)), plasma levels of leptin were significantly higher in women with overweight and obesity (3905.97±463.91 pg/ml vs 1835.17±533.9 pg/ml) (p<0.002). Patient gender could not be demonstrated to influence prognosis. During the two years we recorded one or more readmissions in 26 patients (44%). The analysis of time till readmission using Kaplan-Meier curves, showed that leptin level (cut-off 2000 pg/ml, HR 0.38, 95% CI 0.17-0.83; p=0.01) and BMI (cut-off 28 kg/m(2), HR 0.3164, 95% CI 0.145-0.0689; p<0.01) were significantly associated with prognosis. Conclusion: Patients with plasma levels of leptin >2000 pg/ml and BMI >28kg/m(2) had a better prognosis, suggesting a protective role of leptin in overweight/mild obesity. |
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| فهرسة مساهمة: | Keywords: coronary heart disease; leptin; obesity; owerweight; prognosis |
| تواريخ الأحداث: | Date Created: 20160323 Date Completed: 20160323 Latest Revision: 20201001 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4777471 |
| DOI: | 10.15386/cjmed-524 |
| PMID: | 27004027 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1222-2119 |
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| DOI: | 10.15386/cjmed-524 |