دورية أكاديمية
Diversity in exon 5 of HLA-C(∗)04:01:01G is significant in anthropological studies.
العنوان: | Diversity in exon 5 of HLA-C(∗)04:01:01G is significant in anthropological studies. |
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المؤلفون: | Dunn PP; Tissue Typing Laboratory, New Zealand Blood Service, 71 Great South Road, Epsom, Auckland, New Zealand. Electronic address: paul.dunn@uhl-tr.nhs.uk., Lamb G; Tissue Typing Laboratory, New Zealand Blood Service, 71 Great South Road, Epsom, Auckland, New Zealand., Selwyn C; Tissue Typing Laboratory, New Zealand Blood Service, 71 Great South Road, Epsom, Auckland, New Zealand., Compton J; Tissue Typing Laboratory, New Zealand Blood Service, 71 Great South Road, Epsom, Auckland, New Zealand., Yang E; Tzu Chi Stem Cell Registry, Hualien, Taiwan., Maiers M; National Marrow Donor Program, Minneapolis, USA., Fernandez-Vina M; Department of Pathology, Stanford University Medical School, Stanford, CA, USA. |
المصدر: | Human immunology [Hum Immunol] 2016 May; Vol. 77 (5), pp. 426-8. Date of Electronic Publication: 2016 Mar 24. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: United States NLM ID: 8010936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1166 (Electronic) Linking ISSN: 01988859 NLM ISO Abbreviation: Hum Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [New York] Elsevier/North-Holland. |
مواضيع طبية MeSH: | Native Hawaiian or Other Pacific Islander*, Exons/*genetics, Anthropology ; Gene Frequency ; Genetic Variation ; Haplotypes ; Histocompatibility ; Histocompatibility Testing ; Humans ; New Zealand ; Polymorphism, Genetic ; Stem Cell Transplantation ; United States |
مستخلص: | Polymorphisms in Human Leukocyte Antigen (HLA) class I genes are generally considered to be relevant only if they reside in exons 2 and 3 or if they affect the expression of the allele. HLA-C(∗)04:82 differs from the common HLA-C(∗)04:01:01 by having a 9 nucleotide, or 3 amino acid duplication, in exon 5. Having observed HLA-C(∗)04:82 in a New Zealand Maori stem cell patient, we have attempted to examine the prevalence of this allele in different ethnicities. Although our studies are in a limited number of patients and donors, they have revealed that, in the Pacific region, HLA-C(∗)04:82 appears to be the most common allele of the HLA-C(∗)04:01:01G group of alleles, notably in Filippinos and in Maori/Polynesians. In these populations this allele has characteristic HLA-ABCDRB1 haplotypes. Thus, our studies have shown that polymorphisms outside of the clinically important exons can be considered to be relevant in anthropological studies. (Copyright © 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.) |
التعليقات: | Erratum in: Hum Immunol. 2016 Oct;77(10):1004. (PMID: 27345146) |
فهرسة مساهمة: | Keywords: Anthropology; Diversity; HLA polymorphism; Haplotype |
تواريخ الأحداث: | Date Created: 20160329 Date Completed: 20170217 Latest Revision: 20211204 |
رمز التحديث: | 20221213 |
DOI: | 10.1016/j.humimm.2016.03.007 |
PMID: | 27018403 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1879-1166 |
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DOI: | 10.1016/j.humimm.2016.03.007 |