دورية أكاديمية
أعرض في EDS

Diversity in exon 5 of HLA-C(∗)04:01:01G is significant in anthropological studies.

التفاصيل البيبلوغرافية
العنوان: Diversity in exon 5 of HLA-C(∗)04:01:01G is significant in anthropological studies.
المؤلفون: Dunn PP; Tissue Typing Laboratory, New Zealand Blood Service, 71 Great South Road, Epsom, Auckland, New Zealand. Electronic address: paul.dunn@uhl-tr.nhs.uk., Lamb G; Tissue Typing Laboratory, New Zealand Blood Service, 71 Great South Road, Epsom, Auckland, New Zealand., Selwyn C; Tissue Typing Laboratory, New Zealand Blood Service, 71 Great South Road, Epsom, Auckland, New Zealand., Compton J; Tissue Typing Laboratory, New Zealand Blood Service, 71 Great South Road, Epsom, Auckland, New Zealand., Yang E; Tzu Chi Stem Cell Registry, Hualien, Taiwan., Maiers M; National Marrow Donor Program, Minneapolis, USA., Fernandez-Vina M; Department of Pathology, Stanford University Medical School, Stanford, CA, USA.
المصدر: Human immunology [Hum Immunol] 2016 May; Vol. 77 (5), pp. 426-8. Date of Electronic Publication: 2016 Mar 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: United States NLM ID: 8010936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1166 (Electronic) Linking ISSN: 01988859 NLM ISO Abbreviation: Hum Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [New York] Elsevier/North-Holland.
مواضيع طبية MeSH: Native Hawaiian or Other Pacific Islander*, Exons/*genetics, Anthropology ; Gene Frequency ; Genetic Variation ; Haplotypes ; Histocompatibility ; Histocompatibility Testing ; Humans ; New Zealand ; Polymorphism, Genetic ; Stem Cell Transplantation ; United States
مستخلص: Polymorphisms in Human Leukocyte Antigen (HLA) class I genes are generally considered to be relevant only if they reside in exons 2 and 3 or if they affect the expression of the allele. HLA-C(∗)04:82 differs from the common HLA-C(∗)04:01:01 by having a 9 nucleotide, or 3 amino acid duplication, in exon 5. Having observed HLA-C(∗)04:82 in a New Zealand Maori stem cell patient, we have attempted to examine the prevalence of this allele in different ethnicities. Although our studies are in a limited number of patients and donors, they have revealed that, in the Pacific region, HLA-C(∗)04:82 appears to be the most common allele of the HLA-C(∗)04:01:01G group of alleles, notably in Filippinos and in Maori/Polynesians. In these populations this allele has characteristic HLA-ABCDRB1 haplotypes. Thus, our studies have shown that polymorphisms outside of the clinically important exons can be considered to be relevant in anthropological studies.
(Copyright © 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
التعليقات: Erratum in: Hum Immunol. 2016 Oct;77(10):1004. (PMID: 27345146)
فهرسة مساهمة: Keywords: Anthropology; Diversity; HLA polymorphism; Haplotype
تواريخ الأحداث: Date Created: 20160329 Date Completed: 20170217 Latest Revision: 20211204
رمز التحديث: 20221213
DOI: 10.1016/j.humimm.2016.03.007
PMID: 27018403
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1166
DOI:10.1016/j.humimm.2016.03.007