دورية أكاديمية
أعرض في EDS

Osteoarthritis: Pathology, Mouse Models, and Nanoparticle Injectable Systems for Targeted Treatment.

التفاصيل البيبلوغرافية
العنوان: Osteoarthritis: Pathology, Mouse Models, and Nanoparticle Injectable Systems for Targeted Treatment.
المؤلفون: Holyoak DT; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853-7501, USA., Tian YF; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853-7501, USA., van der Meulen MC; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853-7501, USA. mcv3@cornell.edu.; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853-7501, USA. mcv3@cornell.edu., Singh A; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853-7501, USA. as2833@cornell.edu.
المصدر: Annals of biomedical engineering [Ann Biomed Eng] 2016 Jun; Vol. 44 (6), pp. 2062-75. Date of Electronic Publication: 2016 Apr 04.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 0361512 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-9686 (Electronic) Linking ISSN: 00906964 NLM ISO Abbreviation: Ann Biomed Eng Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : New York : Springer Science + Business Media
Original Publication: New York, Academic Press.
مواضيع طبية MeSH: Disease Models, Animal*, Nanoparticles/*toxicity , Osteoarthritis, Knee/*chemically induced , Osteoarthritis, Knee/*diagnostic imaging , Osteoarthritis, Knee/*metabolism, Animals ; Humans ; Injections, Intra-Articular ; Mice
مستخلص: Osteoarthritis (OA) is a progressive, degenerative disease of articulating joints that not only affects the elderly, but also involves younger, more active individuals with prolonged participation in high physical-demand activities. Thus, effective therapies that are easy to adopt clinically are critical in limiting the societal burden associated with OA. This review is focused on intra-articular injectable regimens and provides a comprehensive look at existing in vivo models of OA that might be suitable for developing, testing, and finding a cure for OA by intra-articular injections. We first discuss the pathology, molecular mechanisms responsible for the initiation and progression of OA, and challenges associated with disease-specific targeting of OA. We proceed to discuss available animal models of OA and provide a detailed perspective on the use of mouse models in studies of experimental OA. We finally provide a closer look at intra-articular injectable treatments for OA, focusing on biomaterials-based nanoparticles, and provide a comprehensive overview of the various nanometer-size ranges studied.
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معلومات مُعتمدة: R21 AR064034 United States AR NIAMS NIH HHS; RC4 AR060546 United States AR NIAMS NIH HHS; R01 AG028664 United States AG NIA NIH HHS; R01 AG022021 United States AG NIA NIH HHS; P30 AR046121 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: In vivo models; Interleukins; Intra-articular; Nanoparticles; Proteases
تواريخ الأحداث: Date Created: 20160406 Date Completed: 20170817 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4880528
DOI: 10.1007/s10439-016-1600-z
PMID: 27044450
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-9686
DOI:10.1007/s10439-016-1600-z