دورية أكاديمية
A genome editing primer for the hematologist.
| العنوان: | A genome editing primer for the hematologist. |
|---|---|
| المؤلفون: | Hoban MD; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA; and Department of Pediatrics, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA., Bauer DE; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA; and Department of Pediatrics, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA. |
| المصدر: | Blood [Blood] 2016 May 26; Vol. 127 (21), pp. 2525-35. Date of Electronic Publication: 2016 Apr 06. |
| نوع المنشور: | Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York] : Elsevier Original Publication: New York, Grune & Stratton [etc.] |
| مواضيع طبية MeSH: | Gene Editing/*methods , Hematologic Diseases/*genetics , Hematologic Diseases/*therapy , Targeted Gene Repair/*methods, Animals ; Humans |
| مستخلص: | Gene editing enables the site-specific modification of the genome. These technologies have rapidly advanced such that they have entered common use in experimental hematology to investigate genetic function. In addition, genome editing is becoming increasingly plausible as a treatment modality to rectify genetic blood disorders and improve cellular therapies. Genome modification typically ensues from site-specific double-strand breaks and may result in a myriad of outcomes. Even single-strand nicks and targeted biochemical modifications that do not permanently alter the DNA sequence (epigenome editing) may be powerful instruments. In this review, we examine the various technologies, describe their advantages and shortcomings for engendering useful genetic alterations, and consider future prospects for genome editing to impact hematology. (© 2016 by The American Society of Hematology.) |
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| معلومات مُعتمدة: | United Kingdom Wellcome Trust; K08 DK093705 United States DK NIDDK NIH HHS; T32 HL007574 United States HL NHLBI NIH HHS |
| تواريخ الأحداث: | Date Created: 20160408 Date Completed: 20170623 Latest Revision: 20210202 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4882802 |
| DOI: | 10.1182/blood-2016-01-678151 |
| PMID: | 27053532 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1528-0020 |
|---|---|
| DOI: | 10.1182/blood-2016-01-678151 |