دورية أكاديمية
Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification.
| العنوان: | Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification. |
|---|---|
| المؤلفون: | Paloian NJ; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Leaf EM; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Giachelli CM; Department of Bioengineering, University of Washington, Seattle, Washington, USA. Electronic address: ceci@uw.edu. |
| المصدر: | Kidney international [Kidney Int] 2016 May; Vol. 89 (5), pp. 1027-1036. Date of Electronic Publication: 2016 Mar 09. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Phosphates*, Aorta, Abdominal/*metabolism , Aorta, Thoracic/*metabolism , Aortic Diseases/*prevention & control , Kidney/*metabolism , Nephrocalcinosis/*prevention & control , Osteopontin/*metabolism , Vascular Calcification/*prevention & control, Animals ; Aorta, Abdominal/pathology ; Aorta, Thoracic/pathology ; Aortic Diseases/genetics ; Aortic Diseases/metabolism ; Aortic Diseases/pathology ; Biomarkers/blood ; Bone Remodeling ; Diet ; Disease Models, Animal ; Female ; Fibroblast Growth Factor-23 ; Fibroblast Growth Factors/blood ; Kidney/pathology ; Mice, Inbred DBA ; Mice, Knockout ; Nephrocalcinosis/genetics ; Nephrocalcinosis/metabolism ; Nephrocalcinosis/pathology ; Osteopontin/deficiency ; Osteopontin/genetics ; Vascular Calcification/genetics ; Vascular Calcification/metabolism ; Vascular Calcification/pathology |
| مستخلص: | Pathologic calcification is a significant cause of increased morbidity and mortality in patients with chronic kidney disease. The precise mechanisms of ectopic calcification are not fully elucidated, but it is known to be caused by an imbalance of procalcific and anticalcific factors. In the chronic kidney disease population, an elevated phosphate burden is both highly prevalent and a known risk factor for ectopic calcification. Here we tested whether osteopontin, an inhibitor of calcification, protects against high phosphate load-induced nephrocalcinosis and vascular calcification. Osteopontin knockout mice were placed on a high phosphate diet for 11 weeks. Osteopontin deficiency together with phosphate overload caused uremia, nephrocalcinosis characterized by substantial renal tubular and interstitial calcium deposition, and marked vascular calcification when compared with control mice. Although the osteopontin-deficient mice did not exhibit hypercalcemia or hyperphosphatemia, they did show abnormalities in the mineral metabolism hormone fibroblast growth factor-23. Thus, endogenous osteopontin plays a critical role in the prevention of phosphate-induced nephrocalcinosis and vascular calcification in response to high phosphate load. A better understanding of osteopontin's role in phosphate-induced calcification will hopefully lead to better biomarkers and therapies for this disease, especially in patients with chronic kidney disease and other at-risk populations. (Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | 5T32DK7662-22 United States DK NIDDK NIH HHS; HL62329 United States HL NHLBI NIH HHS; R01 HL062329 United States HL NHLBI NIH HHS; HL114611 United States HL NHLBI NIH HHS; HL081785 United States HL NHLBI NIH HHS; R01 HL114611 United States HL NHLBI NIH HHS; T32 DK007662 United States DK NIDDK NIH HHS; R01 HL081785 United States HL NHLBI NIH HHS; P30 DK017047 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: calcium; fibroblast growth factor-23; parathyroid hormone; phosphate; uremia; vascular calcification |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Phosphates) 0 (Spp1 protein, mouse) 106441-73-0 (Osteopontin) 62031-54-3 (Fibroblast Growth Factors) 7Q7P4S7RRE (Fibroblast Growth Factor-23) |
| تواريخ الأحداث: | Date Created: 20160417 Date Completed: 20170117 Latest Revision: 20211203 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4834144 |
| DOI: | 10.1016/j.kint.2015.12.046 |
| PMID: | 27083280 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1523-1755 |
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| DOI: | 10.1016/j.kint.2015.12.046 |