دورية أكاديمية
أعرض في EDS

Maternal seizures can affect the brain developing of offspring.

التفاصيل البيبلوغرافية
العنوان: Maternal seizures can affect the brain developing of offspring.
المؤلفون: Cossa AC; Departamento de Neurologia e Neurocirurgia - Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, UNIFESP, Rua Pedro de Toledo, 669, 2° Andar, São Paulo, SP, Brasil. carol_cossa@hotmail.com., Lima DC; Departamento de Neurologia e Neurocirurgia - Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, UNIFESP, Rua Pedro de Toledo, 669, 2° Andar, São Paulo, SP, Brasil., do Vale TG; Centro Universitário São Camilo, Av. Nazaré, 1501, São Paulo, SP, Brasil., de Alencar Rocha AK; Departamento de Neurologia e Neurocirurgia - Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, UNIFESP, Rua Pedro de Toledo, 669, 2° Andar, São Paulo, SP, Brasil., da Graça Naffah-Mazzacoratti M; Departamento de Neurologia e Neurocirurgia - Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, UNIFESP, Rua Pedro de Toledo, 669, 2° Andar, São Paulo, SP, Brasil.; Departamento de Bioquímica, Universidade Federal de São Paulo, UNIFESP - Rua 3 de maio, 100, São Paulo, BR, Brasil., da Silva Fernandes MJ; Departamento de Neurologia e Neurocirurgia - Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, UNIFESP, Rua Pedro de Toledo, 669, 2° Andar, São Paulo, SP, Brasil., Amado D; Departamento de Neurologia e Neurocirurgia - Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, UNIFESP, Rua Pedro de Toledo, 669, 2° Andar, São Paulo, SP, Brasil.
المصدر: Metabolic brain disease [Metab Brain Dis] 2016 Aug; Vol. 31 (4), pp. 891-900. Date of Electronic Publication: 2016 Apr 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Amsterdam : Springer
Original Publication: New York : Plenum, c1986-
مواضيع طبية MeSH: Blood Glucose/*metabolism , Hippocampus/*metabolism , Prenatal Exposure Delayed Effects/*metabolism , Seizures/*metabolism, Animals ; Female ; Male ; Pilocarpine ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects/blood ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Rats, Wistar ; Seizures/blood ; Seizures/chemically induced ; bcl-2-Associated X Protein/metabolism
مستخلص: To elucidate the impact of maternal seizures in the developing rat brain, pregnant Wistar rats were subjected to the pilocarpine-induced seizures and pups from different litters were studied at different ages. In the first 24 h of life, blood glucose and blood gases were analyzed. (14)C-leucine [(14)C-Leu] incorporation was used to analyze protein synthesis at PN1, and Western Blot method was used to analyze protein levels of Bax, Bcl-2 and Poly(ADP-ribose) polymerase-1 (PARP-1) in the hippocampus (PN3-PN21). During the first 22 days of postnatal life, body weight gain, length, skull measures, tooth eruption, eye opening and righting reflex have been assessed. Pups from naive mothers were used as controls. Experimental pups showed a compensated metabolic acidosis and hyperglycemia. At PN1, the [(14)C-Leu] incorporation into different studied areas of experimental pups was lower than in the control pups. During development, the protein levels of Bax, Bcl-2 and PARP-1 in the hippocampus of experimental pups were altered when compared with control pups. A decreased level of pro- and anti-apoptotic proteins was verified in the early postnatal age (PN3), and an increased level of pro-apoptotic proteins concomitant with a reduced level of anti-apoptotic protein was observed at the later stages of the development (PN21). Experimental pups had a delay in postnatal growth and development beyond disturb in protein synthesis and some protein expression during development. These changes can be result from hormonal alterations linked to stress and/or hypoxic events caused by maternal epileptic seizures during pregnancy.
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فهرسة مساهمة: Keywords: Development; Epilepsy; Offspring; Pilocarpine; Pregnancy
المشرفين على المادة: 0 (Bax protein, rat)
0 (Blood Glucose)
0 (Proto-Oncogene Proteins c-bcl-2)
0 (bcl-2-Associated X Protein)
01MI4Q9DI3 (Pilocarpine)
EC 2.4.2.30 (Parp1 protein, rat)
EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1)
تواريخ الأحداث: Date Created: 20160418 Date Completed: 20180112 Latest Revision: 20181113
رمز التحديث: 20240628
DOI: 10.1007/s11011-016-9825-y
PMID: 27085526
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-7365
DOI:10.1007/s11011-016-9825-y